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Pharmaceuticals

Pharmaceuticals

Are you in need of the best drug quality, full compliance and data integrity?

Anton Paar offers a wide range of scientific and analytical instrumentation used in R&D, production, process control, and quality control in the pharmaceutical, cosmetics, and biotech industries and in life sciences. These measurement solutions include refractometry, polarimetry, density, particle analysis, microwave synthesis and digestion, rheometry, and many others.

Additionally, we offer a comprehensive pharmaceutical compliance package, including 21 CFR Part 11 compliance, and installation services. This makes it easy and cost-efficient to incorporate Anton Paar instruments into your regulated environment. More than 1000 instruments and instrument combinations have been successfully qualified with our Pharma Qualification Package and have subsequently passed numerous audits.

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Anton Paar Products

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Abbemat Heavy Duty

Abbemat Heavy Duty Line

Abbemat WR/MW, Multi wavelengt refractometer

Abbemat MW Multiwavelengths Refractometer

Abbemat Performance and Performance Plus

Abbemat Performance and Performance Plus Line

With its extended low temperature range the automatic Abel closed cup tester can measure flash points or detect flammable vapors by the flash/no flash method

Abel Flash Point Tester: ABA 4

Automatisches Verdünnungs- und Dosiersystem DDS

Automatic Dilution and Dosage System: DDS

Automatisches Prozesspolarimeter Propol

Automatic Process Polarimeter: Propol

Ball Mill BM500

Cora 7X00 Raman Spectrometer with Fiber-optic probe

Benchtop Raman spectrometers: Cora 7X00

Cryo & Humidity Chamber CHC plus+ is a unique combination of the multi-purpose CHC Cryo & Humidity Chamber and an advanced humidity (RH) generator for the analysis of humidity-dependent and/or temperature-dependent structural changes in materials using X-ray diffraction

Cryo & Humidity Chamber: CHC plus⁺

Density and sound velocity meter: DSA 5000 M

Density meter: DMA™ 1001

Density meter: DMA™ 501

Density meter: DMA™ 4100 M

Density meter: DMA™ 4500 M

Density meter: DMA™ 5000 M

HTR compact: Rheometer - autosampler for high sample throughput

HTR: Rheometer automation for high sample throughput and complex sample handling

HTX: Measurement of viscosity, density, concentration of liquids, highly automated and expandable

Handheld Raman spectrometer: Cora 100

Handheld density meter: DMA 35 Basic

HPA-S represents the ultimate performance in wet chemical high pressure digestion sample preparation for AAS, ICP and Voltammetry. The HPA-S acid digestion method is an internationally recognized reference procedure and is in operation as a high-performance routine instrument in numerous laboratories.

High Pressure Digestion: HPA-S High Pressure Asher

High-precision thermometers: MKT 50 and MKT 10

Litesizer™ 100

Litesizer™ 500

Low-Temperature Chamber: TTK 600

MCP 100 Modular Circular Polarimeter

MCP 150

MCP 150 Modular Compact Polarimeter

Surface Testing Platform for scratch (Micro Scratch, MST³) and indentation (Microindentation, MHT³ and Ultra Nano indentation, UNHT³) in order to identify coating adhesion, scratch resistance, hardness and elastic modulus of materials.

Micro Combi Tester (MCT³)

Micro Scratch Tester (MST³)

Microindentation Tester (MHT³)

Microwave Digestion System: Multiwave GO

Rotor 16SOLV HF100 expands the possibilities of Multiwave PRO for the microwave-assisted digestion and extraction of inorganic and organic samples and is easily upgraded for acid digestion applications by interchanging screw caps.

Microwave Digestion and Extraction: Rotor 16SOLV HF100

Rotor 16SOLV MF100 expands the possibilities of Multiwave PRO for the microwave-assisted digestion and extraction of inorganic and organic samples and is easily upgraded for acid digestion applications by interchanging screw caps.

Microwave Digestion and Extraction: Rotor 16SOLV MF100

The acid digestion rotor 16HF100 with 16 high pressure vessels is designed for high sample throughput and efficient handling.

Microwave Digestion: Rotor 16HF100

The acid digestion rotor 16MF100 with 16 pressure vessels is designed for high sample throughput and efficient handling.

Microwave Digestion: Rotor 16MF100

Rotor 8EVAP is an innovative accessory for microwave evaporation with the modular Multiwave PRO microwave sample preparation system. It greatly simplifies and accelerates the microwave-assisted evaporation of acids and concentration of aqueous sample solutions in 8 vessels simultaneously.

Microwave Evaporation: Rotor 8EVAP

The Multiwave PRO microwave reaction system serves two groups: professionals in trace analysis and synthetic chemistry.

Microwave Reaction System: Multiwave PRO

Based on a revolutionary new technique, the all-new Masterwave BTR benchtop reactor for the first time transfers microwave synthesis to the kilolab. Productivity in your lab is considerably increased up to kilogram amounts per day. The benchtop reactor’s magnetically driven paddle stirrer provides independent stirring regimes for individual content. Due its rising-sensor temperature measurement technique, Masterwave BTR features the high temperature accuracy required for direct method transfer from any smaller microwave device.

Microwave Synthesis in the Kilolab: Masterwave BTR

Microwave Synthesis: Monowave 400/200

Rotor 1DRY is the ideal accessory for efficient handling of samples prior to digestion. Microwave-assisted drying takes a quarter of the time required by conventional methods, without carbonization or contamination of samples.

Microwave-assisted Drying: Rotor 1DRY

Modular Circular Polarimeter: MCP 5100/5300/5500

Monowave 450: Automated Microwave-assisted Extraction

Multiparameter Analysis: Modulyzer

Nanoindentation Tester (NHT³)

Oxy 510 Inline Oxygen Sensor

PC-controllable Alignment Stage

Penetrometer PNR 12 with accessories for cone penetration and needle penetration.

Penetrometer: PNR 12

The automatic Pensky-Martens closed cup tester features a fire extinguishing device, a patented connection system, gas and electric ignition.

Pensky-Martens flash point tester: PMA 5

Cora 5X00 Raman Spectrometer

Portable benchtop Raman spectrometers: Cora 5X00

Portable density meter: DMA 35

The pressure sensor accessory allows for precise reaction control within the reference vessel of Rotor 16MF100 or Rotor 16HF100. The pressure data is transferred to the oven via infrared signal. If required, the pressure sensor accessory can be upgraded to a pressure/temperature sensor accessory.

Pressure Sensor Accessory

Revetest® Scratch Tester (RST³)

Rheometer Measuring Head

Rheometer: MCR 102, MCR 302, MCR 502

Rheometer: MCR 72 and MCR 92

Rolling-ball viscometer Lovis 2000 M/ME

The RheolabQC is the quality control rheometer from Anton Paar. RheolabQC with temperature device C-PTD 180/AIR/QC and with Flexible Cup Holder.

Rotational Rheometer: RheolabQC

Rotational Viscometer ViscoQC 100

Rotational Viscometer ViscoQC 300

The Rotor 4x24MG5 is specially designed for hit-to-lead generation in gram scale and parallel method optimization in microwave synthesis. Its reliable setup features 96 disposable glass vials arranged in ANSI format silicon carbide blocks with a convenient 6x4 matrix for reaction conditions up to 200 °C and 20 bar.

Rotor 4X24MG5

The high-throughput rotor 4x20MGC for parallel processing of smallest sample quantities in biotechnology, medicinal and forensic chemistry comprises up to 80 disposable standard GC/HPLC glass vials placed in silicon carbide (SiC) plates with a compact 5x4 matrix.

Rotor 4x20MGC

The Rotor 64MG5 is specially designed for high throughput and library generation and development in gram scale. Its reliable setup features 64 disposable glass vials arranged in 16 groups of four. Proper sealing with modified screw caps allows the use of 5 mL standard vials for reaction conditions of 200 °C and 20 bar.

Rotor 64MG5

SAXSpace instrument

Routine SAXS/WAXS/BIOSAXS analysis: SAXSpace

SAXS/WAXS/GISAXS laboratory beamline: SAXSpoint 2.0

Snap 51 Portable Alcohol Meter for Distilled Spirits

Software for particle analysis: Kalliope™

Top View mounted T-probe with Rotor 8N of Multiwave PRO.

T-probe

The T-probe S is an immersing sensor for synthesis applicatinos for accurate temperature measurement and temperature control inside the reaction vessel of Rotor 8NXF100 and Rotor 8NXQ80 for Multiwave PRO.

T-probe S

TRB³: Pin-on-disk tribometer

With its extended low temperature range the automatic Tag closed cup tester can measure flash points or detect flammable vapors by the flash/no flash method.

Tag Flash Point Tester: TAG 4

Ultra Nanoindentation Tester (UNHT³)

High Temperature Vacuum Tribometer

Vacuum Tribometer (VTHT / VTRB)

Xsample™ 320

Perfect results with automatic cleaning and needle washing using up to three cleaning solvents.

Xsample™ 530

Pressure/temperature sensor accessory for precise reaction control within the reference vessel of Rotor 16MF100 and/or Rotor 16HF100.

p/T Sensor Accessory

pH ME Beverage Measuring Module and pH ME Measuring Module

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Anton Paar Applications

Application PNR 12: Consistency Measurement According to the European Pharmacopoeia 2.9.9 and the U.S. Pharmacopeia (USP)

Application PNR 12: Consistency Measurement According to the European Pharmacopoeia 2.9.9 and the U.S. Pharmacopeia (USP)

Suitable for products like white or yellow petrolatum (vaselinum album and flavum), ointment, wax and carboxymethylcellulose sodium paste.

Application PNR 12: Consistency of Carboxymethylcellulose Sodium Paste

Application PNR 12: Consistency of Carboxymethylcellulose Sodium Paste

The penetrometer PNR 12 allows a rating of the plasticity or consistency of carboxymethylcellulose sodium paste containing products.

Application PNR 12: Consistency of Pharmaceutical Products

Application PNR 12: Consistency of Pharmaceutical Products

The Penetrometer PNR 12 is suitable for consistency measurements required in the pharmaceutical industry. Various test kits are available for different pharmaceutical products and standards like the official WHO method European Pharmacopoeia 2.

Applications of nanoindentation in biology and medicine

Applications of nanoindentation in biology and medicine

Nanoindentation for biological materials

Continuous Monitoring of Hydrogen Peroxide

Continuous Monitoring of Hydrogen Peroxide

Relevant for detergents/cleaners, descaling agent, beverages, food industry, pharmaceuticals, personal care

Correlating Viscosity and Particle Size Parameters determined by Small Angle X-Ray Scattering Studies of concentrated MAb Solutions

Correlating Viscosity and Particle Size Parameters determined by Small Angle X-Ray Scattering Studies of concentrated MAb Solutions

Monoclonal antibodies (MAb) solutions are a major class of biopharmaceuticals with various applications. However, challenges like a high viscosity at the required MAb concentrations need to be addressed at an early development stage.

Cross-selling with MCP | Reliable Partner for Pharmaceutical Industries

The pharmaceutical market shows a strong demand for efficient and improved synthesis methods of active components (APIs) as well as for effective analysis methods.

Determination of Camphor by Polarimetry

Determination of Camphor by Polarimetry

Camphor is naturally produced by trees of the laurel family. It has a strong aromatic odour and is used for various medical and non-medical applications.

Determination of Glucosamine via Polarimetry

Determination of Glucosamine via Polarimetry

Glucosamine is used as a joint supplement for the treatment of arthralgia and osteoarthritis. In order to have high-quality products the optical rotation of glucosamine needs to be analyzed via polarimetry.

Determination of the Enantiomeric Purity of Dextromethorphan Hydrobromide

Determination of the Enantiomeric Purity of Dextromethorphan Hydrobromide

Dextromethorphan, the dextrorotatory enantiomer of methorphan, serves as an antitussive drug. According to the US pharmacopoeia, the optical rotation of dextromethorphan hydrobromide has to be measured at a wavelength of 325 nm whereas the EU pharmacopoeia

Fast Structure Analysis of Pharmaceutical Excipients by SWAXS for Product Quality Control

Fast Structure Analysis of Pharmaceutical Excipients by SWAXS for Product Quality Control

The nanostructure of pharmaceutical excipients used as taste masking agents was rapidly determined for quick quality control with the SAXSpace system.

Glycerol

Glycerol

Glycerol is used in various industries as a moisturizer, a thickener, as antifreeze or as a precursor for explosives. Its quality as well as its concentration in solution can be determined by using refractometry.

Gold nanoparticles: Size matters, and so does stability

Gold nanoparticles: Size matters, and so does stability

Gold nanoparticles are now used in many fields, from medicine to electronics, but each application has specific particle-size and stability requirements. Gold nanoparticles can be easily monitored with the Litesizer™ 500.

Identifying three different particle sizes in one sample with DLS

Identifying three different particle sizes in one sample with DLS

Particle suspensions often contain more than one size of particle. However, many particle analyzers cannot resolve particle mixtures, instead they detect an average of all sizes. The Litesizer™ 500 can detect three sizes in one sample.

Improve Digestion Quality and Save Money – Microwave Digestion rules out Open Digestion

Improve Digestion Quality and Save Money – Microwave Digestion rules out Open Digestion

Reliable elemental analysis results need robust sample preparation to destroy sample matrices or to separate matrix from analytes. The sample preparation step is by far the most error-prone and critical step of the analytical procedure.

Intelligent Quartz Control Plates for Polarimetric Calibration and Adjustment

Intelligent Quartz Control Plates for Polarimetric Calibration and Adjustment

Modern polarimeters are calibrated or adjusted with intelligent quartz control plates that do not require manual data entry in order to ensure data traceability.

L-Rix 510: Determination of Concentration on Producing Dialysis Products

L-Rix 510: Determination of Concentration on Producing Dialysis Products

L-Rix 510 – Enjoy the simplicity of refractive index measurements without maintenance or adjustments.

Mesoporous thin films - Investigating the structure of multi-layered films by GISAXS

Mesoporous thin films - Investigating the structure of multi-layered films by GISAXS

Single- and double-layered mesoporous thin films have been analyzed by GISAXS for their structural properties using the SAXSpoint system.

Nanoparticles for Ceramics: Size, Stability & pH

Nanoparticles for Ceramics: Size, Stability & pH

In nanoparticle suspensions that will be used in ceramics, particle size and stability are of vital importance. Suspension stability is essential to ensure that the particles to stay in suspension, and maintain constant particle size.

Nanotribological properties of Diamond like carbon thin flexible films on ACM rubber

Nanotribological properties of Diamond like carbon thin flexible films on ACM rubber

Pharma, Cosmetics - Determining the Rheological Properties of Pharmaceutical Products

Pharma, Cosmetics - Determining the Rheological Properties of Pharmaceutical Products

The rheological characterisation of microemulsions with the Rotational Rheometer RheolabQC gives essential information about their properties and the customer’s evaluation of the end product.

Polarimeters for Processing Applications

Polarimeters for Processing Applications

The Propol process polarimeter is ideal for process applications on chiral compounds such as sugars and pharmaceuticals. It is designed to be placed inline or in bypass allowing continuous measurements.

Polarimetric Determination of Lactose Content in High Lactose Dairy Products

Polarimetric Determination of Lactose Content in High Lactose Dairy Products

The quality of milk and milk powders depends, among others, on the lactose content. The lactose needs to be extracted from dairy products having high lactose content (e.g. milk and milk powders) before using the polarimeter for concentration determination.

Quality Control in Drugs

Quality Control in Drugs

Polarimeters are essential in drug quality control to ensure the enantiomeric purity and therefore efficacy of pharmaceutical drugs.

Quality Control of Saline Solution

Quality Control of Saline Solution

Abbemat refractometers from Anton Paar are valuable instruments for the precise analysis of concentration and purity of saline solutions.

Quality control of pharmaceutical excipients during storage and processing

Quality control of pharmaceutical excipients during storage and processing

The structure of pharmaceutical excipients as a function of storage time and temperature was analyzed by small- and wide-angle X-ray scattering using the SAXSpace system.

Refractive Index of Essential Oils

Refractive Index of Essential Oils

The refractive index of essential oils is a quickly measured, easily generated quality parameter. Moreover, it helps to differentiate between different essential oils.

Refractometric analysis of fats and oils

Refractometric analysis of fats and oils

The refractive index or butyro value of animal and vegetable fats and oils is a quickly measured, easily generated quality parameter value. Moreover, it helps to differentiate between different fats, such as butter and margarine.

SAXSpoint with MetalJet Source

SAXSpoint with MetalJet Source

SAXSpoint now integrates the high-brightness MetalJet X-ray source enabling ultra-fast SAXS measurements in the laboratory.

Size and shape of gold nanoparticles in toluene via SAXS

Size and shape of gold nanoparticles in toluene via SAXS

A solution of colloidal gold nanoparticles was characterized for size and shape by the SAXSpace system.

Spherical Nanoindentation of Polyacrylamide Hydrogels using the Bioindenter (BHT)

Spherical Nanoindentation of Polyacrylamide Hydrogels using the Bioindenter (BHT)

Starch Decomposition with Subsequent Polarimetric Content Determination

Starch Decomposition with Subsequent Polarimetric Content Determination

This method is suitable for the determination of starch and high molecular weight starch degradation products in food or feedstuffs in compliance with the EC Commission Directive 86/174/EEC and Council Directive 96/25/EC. Please note that this method requi

Targeting Alzheimer’s disease - studying the fibril structure of the Amyloid beta protein on a laboratory system

Targeting Alzheimer’s disease - studying the fibril structure of the Amyloid beta protein on a laboratory system

The fibril structure of Amyloid beta has been studied with the SAXSpoint 2.0 system.

Temperature-dependent GISAXS studies on thin films

Temperature-dependent GISAXS studies on thin films

The temperature-induced decomposition of a thin film structure has been studied using the SAXSpoint system with the new temperature-controlled GISAXS stage.

The Ultra Nanoindentation Tester: New generation of thermal drift free indentation

The Ultra Nanoindentation Tester: New generation of thermal drift free indentation

The influence of Surface Roughness on Instrumented Indentation Testing (IIT)

The influence of Surface Roughness on Instrumented Indentation Testing (IIT)

5 Reasons

Compliance and data integrity

Our instruments comply with the pharmacopoeia methods stated in the US Pharmacopeia (USP), European Pharmacopoeia (Ph.Eur.) and many other national regulations. The high end instruments and combined instrument setups can be connected to LIMS, the network or USB for easy and secure data transfer. Software features like e.g. audit trail, electronic signature, user management, backup functions and data export for full data integrity minimize the risk of non-compliance. The high accuracy and reliability of our instruments guarantee the lowest possible error ratio. Our requalification service also supports you in case of yearly requalification, change of the instrument’s location, and many other cases.

Pharma Qualification Package and installation service

With Anton Paar’s qualification service your new instrument is ready for routine operation within 1 to 3 working days, reducing the work required by your in-house personnel. More than 1000 instruments and instrument combinations have been successfully qualified with our Pharma Qualification Packages.

To support your compliance and traceability needs, Anton Paar offers more than 40 instrument-specific qualification packages as well as qualified installation support. Pharma Qualification Packages by Anton Paar include much more than the standard IQ/OQ and are prepared individually for every instrument and customer. They include all required documents for complying with relevant regulations like USP 1058, GAMP 5, GMP, and 21 CFR Part 11.

Profit from the expert’s knowledge: End user training

Anton Paar offers end user training to maximize your benefit from our instruments. We strive to share our broad knowledge about instruments, technologies, handling and applications. Our sales and service representatives are highly qualified, trained and certified by the comprehensive Anton Paar internal trainings program.

Multiple parameter measurement for fast and reliable results

Numerous samples such as gels, creams, infusions, APIs, blood samples, essential oils, proteins, and polymers can be investigated by measuring various parameters such as density, viscosity, refractive index, polarimetry, and turbidity. Choose from our comprehensive product portfolio. Individual instruments can be combined easily to make multiparameter measurement systems. Innovative products for high sample throughput using low sample volume or sample recovery are an essential part of our portfolio. Laboratory automation and inline/at-line solutions are provided. These meet pharmaceutical requirements, ranging from R&D to quality control.

You are not alone: Global on-site service

We offer on-site service by highly experienced support staff via a vast network of representatives from 30 subsidiaries and 60 distribution partners. Experts on call and service programs ensure peace of mind, guarantee the highest quality operation throughout an instrument’s lifespan, and reduce standby times. Our different service programs are designed to match individual needs, from the recommended preventive maintenance programs to full repair coverage. In case of a repair, instrument location change, software update or any other reason, our pharma requalification package guarantees that your instrument qualification is up to date and your instrument is compliant throughout its working life.