Biotechnological samples

In-depth study of sample properties to understand complex processes and interactions

Gaining information on the behavior of materials used in fields such as applied immunology, molecular engineering, and genetic engineering can be as simple as determining the concentration of substances at different temperatures – and as complex as characterizing nanostructures and their behavior under different conditions. Anton Paar is a pioneer in many of the required fields of measurement technology and analysis methods.

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Anton Paar Products

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Anton Paar Bioindenter:
UNHT³ Bio

Automated Multipurpose Powder X-Ray Diffractometer:
XRDynamic 500

Benchtop Density Meter:
DMA

Compact Digital Density Meter:
DMA 1001

Compact Raman Spectrometers:
Cora 5001

Density and Sound Velocity Meter:
DSA 5000 M

Abbemat Heavy Duty

Digital Heavy Duty Refractometer:
Abbemat

Digital Performance Refractometer:
Abbemat

Domed Cooling Stage for Four-Circle Goniometers:
DCS 500

Dynamic Image Analyzer:
Litesizer DIA 500

Dynamic Light Scattering Instrument:
Litesizer DLS

Dynamic Shear Rheometer Measuring Head:
DSR 502

Electrokinetic Analyzer for Solid Surface Analysis:
SurPASS 3 Eco

Electrokinetic Analyzer for Solid Surface Analysis:
SurPASS 3 Standard

FTIR Spectrometer:
Lyza 7000

Fully Customizable Laboratory Automation Solution:
HTX

Handheld Raman Spectrometer:
Cora 100

High Vacuum Physisorption Analyzer:
Autosorb 6100

Inline Density Meter:
L-Dens 7400

Inline Density Meter:
L-Dens 7500

Inline Refractometer:
L-Rix

Micro Combi Tester:
MCT³

Microwave Digestion Platform:
Multiwave 5000

Microwave Reactor:
Monowave

Microwave Reactor:
Monowave 200

Microwave Reactor:
Monowave 400

Microwave Reactor:
Monowave 450

Millikelvin Thermometers:
MKT

Modular Compact Polarimeter:
MCP 100

Modular Compact Polarimeter:
MCP 150

Modular Compact Rheometer:
MCR 702e MultiDrive

Modular Compact Rheometer:
MCR 702e Space MultiDrive

Modular Compact Rheometer:
MCR 72/92

Modular Compact Rheometer:
MCR 102e/302e/502e

Motorized Alignment for XRD:
Z-Alignment Stage

Nano Scratch Tester:
NST³

Nanoindentation Tester:
NHT³

Pin-on-disk tribometer:
TRB³

Portable Density Meter:
DMA 35 Standard

Revetest Scratch Tester:
RST³

Rheometer Automation for High Sample Throughput and Complex Sample Handling:
HTR

Rolling-Ball Viscometer:
Lovis 2000 M/ME

Rotational Rheometer:
RheolabQC

SAXS/WAXS/BioSAXS System:
SAXSpace

SAXS/WAXS/GISAXS/USAXS/RheoSAXS Laboratory Beamline:
SAXSpoint 5.0

Ultra Nanoindentation Tester:
UNHT³

High Temperature Vacuum Tribometer

Vacuum Tribometer:
TRB V / THT V

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Benefits

Studying the kinetics of transport processes shown by nanostructured emulsion droplets to ensure successful drug delivery control

When investigating the potential application of micelles as vehicles for the delivery of active ingredients, stability determinations have to be complemented by studying the micelles' internal structure. Since their internal structure depends on their composition, time-resolved SAXS experiments can be used to monitor the structure changes involved in the transport kinetics of nanostructured emulsion droplets, such as the uptake and release of active ingredients like vitamins and enzymes. The main requirements for successful time-resolved SAXS experiments, high intensity along with high resolution, are met by SAXSpace, which delivers high-quality data at short measurement times.

Researching the elastic and mechanical properties of hydrogels

Many hydrogels are considered to be potential candidates for replacement, regeneration, scaffolds, or as growth substrates for soft tissues in the human body. Recent research (Discher et al., 2005; Moers et al., 2013) has shown that the elasticity of the substrate can significantly influence the homeostasis of tissues, which is important for tissue regeneration. Determination of the elastic and mechanical properties of biological substrates is therefore of great interest. Elastic modulus and creep properties can easily be studied with Anton Paar’s Bioindenter as the instrument is compatible with testing in liquids and can operate under various loading modes. The time-dependent response of hydrogels can also be studied.

Determining the intrinsic viscosity and molar mass

The biological effects of hyaluronan can be tailored for pharmaceutical purposes by changing its molar mass. Hyaluronan has a short half-life in the body; for some purposes, e.g. in plastic surgery, its stability has to be increased by increasing the molecular mass. The Lovis 2000 M/ME microviscometer determines the viscosity of dissolved hyaluronan. The intrinsic viscosity is automatically calculated from the relative viscosity of hyaluronan and its solvent. The intrinsic viscosity provides the same information content as the molar mass. Nevertheless, the molar mass can also be calculated according to the Mark-Houwink equation and read directly off the screen. If required, the shear rate dependency can be eliminated by performing an automated zero shear rate extrapolation.

Investigating surface properties to ensure biocompatibility of implants

Surface properties such as the surface charge indicate a surface’s biocompatibility. Depending on the application of a biomaterial, a surface with high or low affinity to proteins is required. In tissue engineering and regenerative medicine, protein adsorption induces the integration of implants while in other cases high protein adhesion may lead to thrombus formation. Zeta potential analysis using Anton Paar’s SurPASS provides information on the surface charge at physiological pH and the chemistry of surface functional groups. The sign and magnitude of the zeta potential are used to estimate the electrostatic interaction between the solid surface and a charged species dissolved in the surrounding aqueous solution.

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