Dynamic Light Scattering Instrument:
Litesizer DLS

Name: Dynamic Light Scattering Instrument: Litesizer DLS 501
Brand: Anton Paar
SKU: 317782

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Model:

Particle sizing from 0.3 nm to 15 µm
Advanced dynamic light scattering at three measurement angles
Determination of zeta potential using patented cmPALS
Molecular mass and refractive index measurements
Fluorescent and polarization filters for all angles

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Key features
Specifications
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Litesizer DLS delivers best-in-class particle sizing with automatic angle selection to prevent errors, while MAPS technology yields the highest-possible peak resolution. Continuous transmittance monitoring detects sedimentation and agglomeration during measurement, enhancing measurement reliability.

Unique to our system, cmPALS and Omega Cuvette improve zeta potential accuracy and repeatability by addressing aging effects and minimizing electrical gradient.

Litesizer DLS also offers fluorescence and polarization filters not only for particle size measurements, but also particle concentration in both MAPS three-angle and single-angle modes.

Key features

Three angles, real-time monitoring for better sizing

Litesizer DLS offers the choice between three different detection angles to measure a wide array of samples, while eliminating errors with automatic angle selection.
The Multi-Angle Particle Sizing (MAPS) measurement mode delivers exceptional resolution, supporting advanced analytical precision.
Unique to the market, our continuous transmission monitoring provides live feedback on sample behavior throughout measurement, giving users instant information on sedimentation or agglomeration. This real-time insight enhances measurement quality and reliability, making our system the optimal choice for accurate and dependable particle analysis.

Market-leading zeta potential analysis

Our dynamic light scattering instrument’s patented cmPALS technique is uniquely designed to eliminate reproducibility uncertainties caused by aging effects.
Additionally, the Omega Cuvette’s innovative design minimizes the gradient in the electrical field, further enhancing reproducibility (± 3 %). With an industry-leading particle size range for zeta potential measurement, from 1.3 nm to 100 µm, our instrument offers the broadest capability available, ensuring precise and consistent results across a vast array of applications.

Kalliope: The benchmark software for particle sizing

The Kalliope software requires very little user training.
Measurements can be performed in only three clicks. Our unique one-page layout provides an instant overview of input parameters, measurement signals and results, giving you everything you need at a glance. Quickly access measurement results with predefined standard reports and organized result summaries.
For more detailed analysis, use the customizable report templates, Excel export options, and advanced analysis functions. Plus, Kalliope is fully compliant with 21 CFR Part 11, ensuring robust data integrity and regulatory adherence.

All the measuring modes you need

Enhance your versatility with Litesizer DLS 701’s particle concentration measurement mode, enabling calibration-free concentration analysis for up to three distinct size populations within a single sample. This mode supports both monodisperse and polydisperse samples across a wide concentration range, whether you’re using single-angle DLS or MAPS.
Additionally, measure the refractive index of solvents at the exact wavelength and temperature of your measurements (European Patent 3 023 770), ensuring maximum accuracy for particle size and zeta potential results. Litesizer DLS 701 and DLS 501 provide precise refractive index measurements within ±0.5 %.
To top it off, the Litesizer DLS series also offers molecular mass measurement.

Most capable filtering options available

The Litesizer DLS 701 and 501 are the only dynamic light scattering instruments on the market that offer users the unique choice between fluorescence and polarization filters which can be applied in all three angle directions. This enables particle concentration analysis, as well as MAPS three-angle or selected single-angle analysis with applied filters – permitting types of analysis not possible with comparable instruments (e.g. concentration determination of quantum dots).

Specifications

	Litesizer DLS 701	Litesizer DLS 501	Litesizer DLS 101
Particle size specifications
Measurement principle	Dynamic Light Scattering (DLS)
Measuring range	0.3 nm to 15 μm* (particle diameter)		0.3 nm to 10 μm* (particle diameter)
Measurement angles	15°, 90°, 175°, Multi-angle particle sizing (MAPS)	15°, 90°, 175°	175°
Min. concentration	0.1 mg/mL (lysozyme) lower than 0.00001 % (0.1 ppm, Latex 100 nm)		0.1 mg/mL (lysozyme)
Max. concentration	50 % w/v (sample-dependent)
Min. sample volume	1.5 µL		12 µL
Accuracy	Better than +/-2 % on NIST traceable standards
Repeatability	Better than +/-2 % on NIST traceable standards
Particle Concentration Specifications
Analysis model	Mie Theory	-	-
Measuring range	10⁸ - 10¹³ particles/mL (sample dependent)	-	-
Size limit	1 µm	-	-
Measurement angles	15°, 90°, 175°, Multi-angle particle sizing (MAPS)	-	-
Min. sample volume	12 µL	-	-
Accuracy	+/- 10 % (sample dependent)	-	-
Repeatability	+/- 5 % (sample dependent)	-	-
Zeta potential specifications
Measuring principle	Electrophoretic Light Scattering (ELS) / cmPALS		-
Measuring range	>= +/-1000 mV		-
Mobility range	10^-11 m²/V.s to 2 x 10^-7 m²/V.s		-
Size range	1.3 nm to 100 µm (diameter)		-
Min. sample concentration	0.1 mg/mL (lysozyme)		-
Max. sample concentration	70 %w/v (sample-dependent)		-
Max. sample conductivity	200 mS/cm		-
Min. sample volume	50 µL (sample-viscosity-dependent)		-
Accuracy	Better than +/-10 %		-
Repeatability	+/-3 %		-
Molecular mass specifications
Measuring principle	Static Light Scattering (SLS)		-
Measuring range (mass)	300 Da to 20 MDa		-
Measuring range (particle size)	Up to 40 nm (diameter)		-
Measurement angle	90°		-
Min. sample concentration	0.1 mg/mL (lysozyme)		-
Accuracy	+/-10 %		-
Repeatability	+/-5 %		-
Transmittance specifications
Measuring range	0 % to 100 %
Min. sample volume	1.5 µL		15 µL
Accuracy	Better than +/-1 %
Refractive index specifications
Measuring range	1.28 to 1.50		-
Min. sample volume	1 mL		-
Accuracy	+/-0.5 %		-
General specifications
Light source	Semiconductor laser diode / 40 mW, 658 nm
Optical filters (fluorescence, vertical and horizontal polarization)	forward, side and backscattering		-
Laser warm-up time	6 min
Temperature control range	0 °C to 120 °C
Ambient operating temperature	10 °C to 35 °C
Humidity	Up to 80 % non-condensing
Dimensions (W, D, H)	450 mm, 505 mm, 135 mm
Weight	Approx. 18 kg (40 lb)		Approx. 16.3 kg (36 lb)