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Particle size analyzer:

  • Particle characterization from the nano- to the micrometer range
  • Particle size measurements via dynamic light scattering at three different measurement angles
  • Determination of zeta potential using patented cmPALS
  • Molecular mass and refractive index measurements
  • Particle size measurements from the nano- to the micrometer range
  • DLS back scatter detection ensures broad concentration range
  • Automatic measurement modes
  • Continuous transmittance measurement 
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The Litesizer series is the perfect choice to characterize nano- and microparticles at the touch of a button. Particles in dispersion as well as peptides or macromolecules in solution can be determined over a broad concentration range, limiting the time for sample preparation. Litesizer 500 includes three measurement angles for particle size determination as well as patented cmPALS technology, which enables zeta potential measurements at low voltages with the highest repeatability and accuracy.

Key features

Litesizer chooses the ideal measurement angle for your sample to ensure the highest data quality

Litesizer chooses the ideal measurement angle for your sample to ensure the highest data quality

The three detection angles for DLS measurements in Litesizer 500 (side-, back-, or forward scattering) allow for optimal parameter settings. With the included automatic angle selection the instrument can define the most appropriate angle for your sample. Litesizer 100 uses the versatile backscatter angle, which is ideal for turbid samples because it reduces multiple scattering events and enables optimal data quality. You get a complete analysis of your sample as the Litesizer series is able to resolve up to three different particle size classes within one measurement. 

Zeta potential measurements down to 0.1 mg/mL for the highest sensitivity

Zeta potential measurements down to 0.1 mg/mL for the highest sensitivity

With Litesizer 500 you can perform zeta potential measurements via electrophoretic light scattering. The patented cmPALS technique (European Patent 2 735 870) allows highly sensitive measurements for meaningful results even at the lowest sample concentration, within significantly shorter measuring times and with minimized sample degradation. This is especially helpful for e.g. peptide solutions. Further, the unique Anton Paar Ω-shaped capillary of the zeta potential cuvettes creates a stable electric field exactly at the measurement position, resulting in highly reproducible zeta potential measurements.

Continuous transmittance measurement for sample monitoring

Continuous transmittance measurement for sample monitoring

The continuously measured transmittance gives you instant feedback about your sample. It further allows automatic optimization of measurement parameters, such as measurement angle, focus position, and duration. The transmittance also provides information about the onset of sedimentation or aggregation within a series measurement.

All-in-one instrument – determination of the refractive index

All-in-one instrument – determination of the refractive index

The refractive index of the sample solvent is a required input parameter for DLS and ELS measurements. While for most particle analyzers these indices must be determined from external sources, Litesizer 500 is able to measure the refractive index at the exact wavelength and temperature of your DLS or ELS measurement (European Patent 3 023 770). This ensures maximum accuracy of particle size and zeta potential results under all experimental conditions. Litesizer 500 determines the refractive index within ±0.5 %, as defined by ISO 22412:2017 concerning the accuracy of the refractive index required for DLS.

Get a clear overview of your measurements with the Kalliope software

Get a clear overview of your measurements with the Kalliope software

The Litesizer series’ measurement software, Kalliope, provides an intuitive one-page workflow. Input parameters, measurement signals, and results are all at hand. The one-page workflow also allows you to start a measurement with only three clicks. Pre-defined standard reports and structured result overviews provide quick access to your measurement result. You can also have a deeper look into the data via the analysis function, Excel export, and customizable report templates. Kalliope is fully compliant with the FDA’s 21 CFR Part 11 regulations. Explore more features of Kalliope here

Technical specifications

Litesizer 500 Litesizer 100
Particle size specifications
Measurement principle Dynamic Light Scattering (DLS)
Measuring range 0.3 nm to 10 μm* (particle diameter)
Measurement angles 15°, 90°, 175° 90°
Min. concentration 0.1 mg/mL (lysozyme)
Max. concentration 50 %w/v (sample-dependent)
Min. sample volume 12 µL
Accuracy Better than +/-2 % on NIST traceable standards
Repeatability Better than +/-2 % on NIST traceable standards
Zeta potential specifications
Measuring principle Electrophoretic Light Scattering (ELS) / cmPALS -
Measuring range >= +/-1000 mV -
Mobility range 10-11 m²/V.s to 2 x 10-7 m²/V.s -
Size range 3.8 nm to 100 µm (diameter) -
Min. sample concentration 0.1 mg/mL (lysozyme) -
Max. sample concentration 70 %w/v (sample-dependent) -
Max. sample conductivity 200 mS/cm -
Min. sample volume 50 µL (sample-viscosity-dependent) -
Accuracy Better than +/-10 % -
Repeatability +/-3 % -
Molecular mass specifications
Measuring principle Static Light Scattering (SLS) -
Measuring range (mass) 980 Da to 20 MDa -
Measuring range (particle size) up to 40 nm (diameter) -
Measurement angle 90° -
Min. sample concentration 0.1 mg/mL (lysozyme) -
Accuracy +/-10 % -
Repeatability +/-5 % -
Transmittance specifications
Measuring range 0 % to 100 %
Min. sample volume 15 µL
Accuracy Better than +/-1 %
Refractive index specifications
Measuring range 1.28 to 1.50 -
Min. sample volume 1 mL -
Accuracy +/-0.5 % -
General specifications
Light source Semiconductor laser diode / 40 mW, 658 nm
Laser warm-up time 6 min
Temperature control range 0 °C to 90 °C
Ambient operating temperature 10 °C to 35 °C
Humidity up to 80 % non-condensing
Dimensions (W, D, H) 460 mm, 485 mm, 135 mm
Weight approx. 18 kg (40 lb) approx. 16.3 kg (36 lb)



ASTM D4001-13
ASTM E2490-09
ASTM E2865-12


ISO 13099-2
ISO 22412


USP 729

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