Medical samples & biomaterials, membranes
Opening up new channels for biomaterials engineering and research
Research on biomaterials, membranes, and medical samples requires high-precision tools which are reliable and intuitive to use. Whether you are investigating chemical processes, the behavior of particles, mechanical or elastic behavior or permeability, Anton Paar has a solution for you.
Anton Paar Products
Abel Flash Point Tester: ABA 4
Anton Paar Bioindenter: UNHT³ Bio
Atomic Force Microscopes: Tosca
Automated Multipurpose Powder X-Ray Diffractometer: XRDynamic 500
Capillary flow porometers for through-pores: Porometer 3G
Compact Raman spectrometers: Cora 5001
Digital heavy duty refractometer: Abbemat
Digital performance refractometer: Abbemat
Dynamic shear rheometer measuring head: DSR 502
Five-station gas pycnometers for true density: PentaPyc and PentaFoam
Fully customizable laboratory automation solution: HTX
Gas sorption analyzer: QUADRASORB evo
Handheld density meter: DMA 35 Basic
High vacuum physisorption/chemisorption analyzers: autosorb iQ
High-pressure volumetric gas sorption analyzer: iSorb
HTR Compact: Rheometer autosampler for high sample throughput
HTR: Rheometer automation for high sample throughput and complex sample handling
Inline refractometer: L-Rix
Mercury intrusion pore size analyzers: PoreMaster
Micro Combi Tester: MCT³
Microwave digestion system: Multiwave 5000
Microwave Digestion System: Multiwave 7000
Microwave digestion system: Multiwave GO Plus
Microwave reactor: Monowave
Modular Compact Rheometer: MCR 72/92
Modular Compact Rheometer: MCR 102e/302e/502e
Nano scratch tester: NST³
Nanoindentation tester: NHT³
Particle size analyzer: Litesizer
Penetrometer: PNR 12
Pin-on-disk tribometer: TRB³
Portable density meter: DMA 35
Revetest® Scratch Tester: RST³
Rolling-ball viscometer: Lovis 2000 M/ME
Rotational Rheometer: RheolabQC
Sample changer: Xsample 320
Sample changer: Xsample 530
SAXS/WAXS/BioSAXS system: SAXSpace
SAXS/WAXS/GISAXS/RheoSAXS laboratory beamline: SAXSpoint 5.0
Single-station gas pycnometers for true density: Ultrapyc
Software solutions for ViscoQC: Software
Surface area analyzer: AutoFlow BET+
Surface area and pore size analyzers: NOVAtouch
Tag Flash Point Tester: TAG 4
Ultra nanoindentation tester: UNHT³
Vacuum and Flow Degasser: FloVac
Vacuum Degasser: XeriPrep
Vacuum Tribometer: TRB V / THT V
Vapor sorption volumetric gas sorption analyzer: VSTAR
XRD software: XRDanalysis
Anton Paar Applications
Protein Mass Determination using Small Angle X-Ray Scattering
The molecular weight of Glucose Isomerase was determined with the SAXSpace small-angle X-ray scattering system. The results are in good agreement with theoretically calculated values from X-ray crystallography data.
Protein Shape Determination by Small Angle X-Ray Scattering
The 3-dimensional shape of Glucose Isomerase in solution was studied with the SAXSpace system. The solution structure of this protein was compared with the crystal structure obtained by X-ray crystallography.
Determination of Camphor by Polarimetry
Camphor is naturally produced by trees of the laurel family. It has a strong aromatic odour and is used for various medical and non-medical applications.
Starch Decomposition with Subsequent Polarimetric Content Determination
This method is suitable for the determination of starch and high molecular weight starch degradation products in food or feedstuffs in compliance with the EC Commission Directive 86/174/EEC and Council Directive 96/25/EC. Please note that this method requi
Refractive Index of Essential Oils
The refractive index of essential oils is a quickly measured, easily generated quality parameter. Moreover, it helps to differentiate between different essential oils.
Refractometric Analysis of Urine
Acute dehydration poses a significant health risk and can lead to heat stroke and death. Refractometric anaylsis of the urine of patients in hospitals and clinics as well as that of athletes quickly shows vital human health parameters.
Glycerol is used in various industries as a moisturizer, a thickener, as antifreeze or as a precursor for explosives. Its quality as well as its concentration in solution can be determined by using refractometry.
Quality Control in Drugs
Polarimeters are essential in drug quality control to ensure the enantiomeric purity and therefore efficacy of pharmaceutical drugs.
Quality Control of Saline Solution
Abbemat refractometers from Anton Paar are valuable instruments for the precise analysis of concentration and purity of saline solutions.
Improve Digestion Quality and Save Money – Microwave Digestion rules out Open Digestion
Reliable elemental analysis results need robust sample preparation to destroy sample matrices or to separate matrix from analytes. The sample preparation step is by far the most error-prone and critical step of the analytical procedure.
The influence of Surface Roughness on Instrumented Indentation Testing (IIT)
Microwave Assisted Digestion of Diatoms
MD-VF-Auto SEM represents a powerful combination of microwave digestion, vacuum filtration and automated scanning electron microscopy for the qualitative and quantitative determination of diatoms.
In-Situ observation of the scratch/indentation true contact area to provide analysis without being model-dependent
Nanoindentation approach to mechanical testing of extremely soft materials
Nanotribological properties of Diamond like carbon thin flexible films on ACM rubber
Spherical Nanoindentation of Polyacrylamide Hydrogels using the Bioindenter (BHT)
The Ultra Nanoindentation Tester: New generation of thermal drift free indentation
Milk: Know the particles, know the quality
The size of the fat particles in milk can vary, which strongly affects milk quality. Characterizing milk-based particles is fast and accurate with the Litesizer™ 500.
Applications of nanoindentation in biology and medicine
Nanoindentation for biological materials
Intrinsic bone tissue quality is altered in osteo-porosis and selectively influenced by its treatments
Nanoindentation for bone and mineral materials
Identifying three different particle sizes in one sample with DLS
Particle suspensions often contain more than one size of particle. However, many particle analyzers cannot resolve particle mixtures, instead they detect an average of all sizes. The Litesizer™ 500 can detect three sizes in one sample.
An insight into the Structure of Copolymer Surfactants
The structure of inhomogeneous (core-shell) nanoparticles was studied with the SAXSpoint system. The internal structure of Pluronic P123 micelles in water was determined by calculating the radial electron density profile.
Collagen - A Validation Sample for SAXS Systems
The performance of the SAXSpoint 2.0 system is evaluated by measurements of tendon collagen. SAXSpoint 2.0 produces data with excellent resolution in the entire angular range and delivers true 2D SWAXS images.
Understanding Filter Efficiency - Virus Removal in Depth Filtration
Zeta potential, as the indicator for surface charge, helps to predict and to tune the efficiency of filter materials.
Effect of Bleaching on the Streaming Potential of Human Hair
The streaming potential method reveals the changes of the hair surface upon hair treatment processes and supports the optimization of cosmetic products.
Inner Surface Treatment of Haemodialysis Membranes
The zeta potential measurement assists in the improvement of the biocompatibility of haemodialysis membranes.
SAXSpoint with MetalJet Source
SAXSpoint now integrates the high-brightness MetalJet X-ray source enabling ultra-fast SAXS measurements in the laboratory.
Fast SAXS studies of sensitive biological samples
Small-angle X-ray scattering (SAXS) measurements of low-concentrated and radiation-sensitive biological samples using line collimation ensure short measurement time and allow to analyze the low-resolution 3D structure with excellent data quality.
Correlating Viscosity and Particle Size Parameters determined by Small Angle X-Ray Scattering Studies of concentrated MAb Solutions
Monoclonal antibodies (MAb) solutions are a major class of biopharmaceuticals with various applications. However, challenges like a high viscosity at the required MAb concentrations need to be addressed at an early development stage.
Targeting Alzheimer’s disease - studying the fibril structure of the Amyloid beta protein on a laboratory system
The fibril structure of Amyloid beta has been studied with the SAXSpoint 2.0 system.
Size and shape of gold nanoparticles in toluene via SAXS
A solution of colloidal gold nanoparticles was characterized for size and shape by the SAXSpace system.
Differentiating between normal and pathological red blood cells
Anton Paar’s MCR rheometer is an excellent tool for monitoring the rheological characteristics of whole blood. At low shear stress, for example, red blood cells adhere to each other, aggregate, and form rouleaux. Using an MCR with a microscope accessory allows you to monitor changes in blood under various conditions through the microscope lens during the measurement. This combined information enables the correlation of the rheological properties of red blood cells to their aggregation state. Whole blood samples can be investigated according to the Recommendation of the International Committee for Standardization in Hematology.
Investigating the fouling of membranes and improving their biocompatibility
An economical and effective adsorbent for low-density lipoprotein (LDL) in blood is a dialysis membrane which is based on polysulfone with covalently bound heparin. However, problems inherent in the applicability of membranes in hemodialysis are surface-induced blood coagulation and membrane fouling due to irreversible protein adsorption. To improve the biocompatibility of these hemodialysis membranes, the inner surface of the membrane requires modification. A major challenge inherent to this process is the permanent coating with heparin. The grafting of reactive groups onto the polysulfone surface is one route to prepare the interface for the immobilization of such biologically active substances. The SurPASS electrokinetic analyzer is applied for analyzing the inner surface of such hollow-fiber membranes. Comparing the zeta potential of untreated and modified membranes reveals the efficiency of the surface treatment. The isoelectric point, which is obtained automatically, and the zeta potential values at higher pH are an indication that the grafting of reactive groups and the coating with heparin were successful.
Ensuring the safety of IV infusions
A common risk from intravenous infusions is contamination by particles that are not visible to the eye. To detect these unwanted particles and monitor the quality of IV infusions requires an analyzer such as Anton Paar’s Litesizer 500 which determines the particle size and particle size distribution of a solution quickly and from very small sample amounts (from 12 µL). The measurement meets the requirement of the US Pharmacopoeia for parenteral products which defines the size of droplets in emulsions and solutions to be infused or injected.
Assessing the level of trace elements in urine, blood, and hair
Evaluating trace element concentrations using, for example, ICP-MS/ICP-DRCMS and ETAAS requires sample solutions which are completely digested in order to minimize spectral and matrix interferences in the measurement. Microwave-assisted pressure digestion provides one such reliable method of sample preparation. Multiwave PRO, for example, decomposes body fluids and hair to produce high-quality samples in a short period of time.