Medical samples & biomaterials, membranes

Opening up new channels for biomaterials engineering and research

Research on biomaterials, membranes, and medical samples requires high-precision tools which are reliable and intuitive to use. Whether you are investigating chemical processes, the behavior of particles, mechanical or elastic behavior or permeability, Anton Paar has a solution for you. 

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Anton Paar Products

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With its extended low temperature range the automatic Abel closed cup tester can measure flash points or detect flammable vapors by the flash/no flash method

Abel Flash Point Tester: ABA 4

Anton Paar Bioindenter: UNHT³ Bio

Automatisches Prozesspolarimeter Propol

Automatic Process Polarimeter: Propol

Ball mill: BM500

Cora 7X00 Raman Spectrometer with Fiber-optic probe

Benchtop Raman spectrometers: Cora 7X00

Capillary flow porometers: Porometer 3G

Cora 5X00 Raman Spectrometer

Compact Raman spectrometers: Cora 5X00

Density meter: DMA 4100 M

Density meter: DMA 4500 M

Density meter: DMA 5000 M

Abbemat Heavy Duty

Digital heavy duty refractometer: Abbemat

Abbemat Performance and Performance Plus

Digital performance refractometer: Abbemat

Dynamic shear rheometer measuring head: DSR 502

Electrokinetic Analyzer for Routine Solid Surface Analysis: SurPASS™ 3 Eco

Electrokinetic analyzer for solid surface analysis: SurPASS 3

Foam testing Pycnometer: PentaFoam

Fully customizable laboratory automation solution: HTX

Gas Pycnometer: PentaPyc

Gas sorption analyzer: QUADRASORB evo

Handheld density meter: DMA 35 Basic

HPA-S represents the ultimate performance in wet chemical high pressure digestion sample preparation for AAS, ICP and Voltammetry. The HPA-S acid digestion method is an internationally recognized reference procedure and is in operation as a high-performance routine instrument in numerous laboratories.

High Pressure Digestion: HPA-S

HTR Compact: Rheometer autosampler for high sample throughput

HTR: Rheometer automation for high sample throughput and complex sample handling

Inline Refractometer: L-Rix

Mercury intrusion porosimeters: PoreMaster

Micro Combi Tester: MCT³

Micro Scratch Tester: MST³

Microindentation Tester: MHT³

Micropore physi-/chemisorption analyzers: autosorb iQ

The acid digestion rotor 16HF100 with 16 high pressure vessels is designed for high sample throughput and efficient handling.

Microwave digestion rotor: Rotor 16HF100

The acid digestion rotor 16MF100 with 16 pressure vessels is designed for high sample throughput and efficient handling.

Microwave digestion rotor: Rotor 16MF100

Microwave digestion rotor: Rotor 24HVT80

Microwave digestion system: Multiwave GO Plus

Rotor 16SOLV HF100 expands the possibilities of Multiwave PRO for the microwave-assisted digestion and extraction of inorganic and organic samples and is easily upgraded for acid digestion applications by interchanging screw caps.

Microwave extraction rotor: Rotor 16SOLV HF100

Rotor 16SOLV MF100 expands the possibilities of Multiwave PRO for the microwave-assisted digestion and extraction of inorganic and organic samples and is easily upgraded for acid digestion applications by interchanging screw caps.

Microwave extraction rotor: Rotor 16SOLV MF100

Microwave reactor for microwave-assisted extractions: Monowave 450

Rotor 1DRY is the ideal accessory for efficient handling of samples prior to digestion. Microwave-assisted drying takes a quarter of the time required by conventional methods, without carbonization or contamination of samples.

Microwave-assisted drying rotor: Rotor 1DRY

Modular Compact Rheometer: MCR 72/92

Modular Compact Rheometer: MCR 102/302/502

Nano scratch tester: NST³

Nanoindentation tester: NHT³

Particle size analyzer: Litesizer 100

Particle size analyzer: Litesizer 500

Penetrometer PNR 12 with accessories for cone penetration and needle penetration.

Penetrometer: PNR 12

pH value measuring module: pH ME

Pin-on-disk tribometer: TRB³

Portable density meter: DMA 35

Revetest® Scratch Tester: RST³

Rolling-ball viscometer: Lovis 2000 M/ME

The RheolabQC is the quality control rheometer from Anton Paar. RheolabQC with temperature device C-PTD 180/AIR/QC and with Flexible Cup Holder.

Rotational Rheometer: RheolabQC

Sample changer: Xsample 320

Perfect results with automatic cleaning and needle washing using up to three cleaning solvents.

Sample changer: Xsample 530

SAXSpace instrument

SAXS/WAXS/BioSAXS system: SAXSpace

SAXS/WAXS/GISAXS/RheoSAXS laboratory beamline: SAXSpoint 5.0

Surface area analyzer: AutoFlow BET+

Surface area and pore size analyzers: NOVAtouch

Top View mounted T-probe with Rotor 8N of Multiwave PRO.

T-probe

With its extended low temperature range the automatic Tag closed cup tester can measure flash points or detect flammable vapors by the flash/no flash method.

Tag Flash Point Tester: TAG 4

Ultra nanoindentation tester: UNHT³

Ultrapyc series

Vacuum and Flow Degasser: FloVac

Vacuum Degasser: XeriPrep

High Temperature Vacuum Tribometer

Vacuum Tribometer: VTHT / VTRB

Vapor sorption analyzer: VSTAR

Volumetric gas sorption analyzers: iSorb HP

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Quantachrome Products

Anton Paar Applications

Protein Mass Determination using Small Angle X-Ray Scattering

Protein Mass Determination using Small Angle X-Ray Scattering

The molecular weight of Glucose Isomerase was determined with the SAXSpace small-angle X-ray scattering system. The results are in good agreement with theoretically calculated values from X-ray crystallography data.

Protein Shape Determination by Small Angle X-Ray Scattering

Protein Shape Determination by Small Angle X-Ray Scattering

The 3-dimensional shape of Glucose Isomerase in solution was studied with the SAXSpace system. The solution structure of this protein was compared with the crystal structure obtained by X-ray crystallography.

Determination of Camphor by Polarimetry

Determination of Camphor by Polarimetry

Camphor is naturally produced by trees of the laurel family. It has a strong aromatic odour and is used for various medical and non-medical applications.

Starch Decomposition with Subsequent Polarimetric Content Determination

Starch Decomposition with Subsequent Polarimetric Content Determination

This method is suitable for the determination of starch and high molecular weight starch degradation products in food or feedstuffs in compliance with the EC Commission Directive 86/174/EEC and Council Directive 96/25/EC. Please note that this method requi

Refractive Index of Essential Oils

Refractive Index of Essential Oils

The refractive index of essential oils is a quickly measured, easily generated quality parameter. Moreover, it helps to differentiate between different essential oils.

Refractometric Analysis of Urine

Refractometric Analysis of Urine

Acute dehydration poses a significant health risk and can lead to heat stroke and death. Refractometric anaylsis of the urine of patients in hospitals and clinics as well as that of athletes quickly shows vital human health parameters.

Glycerol

Glycerol

Glycerol is used in various industries as a moisturizer, a thickener, as antifreeze or as a precursor for explosives. Its quality as well as its concentration in solution can be determined by using refractometry.

Quality Control in Drugs

Quality Control in Drugs

Polarimeters are essential in drug quality control to ensure the enantiomeric purity and therefore efficacy of pharmaceutical drugs.

Quality Control of Saline Solution

Quality Control of Saline Solution

Abbemat refractometers from Anton Paar are valuable instruments for the precise analysis of concentration and purity of saline solutions.

Improve Digestion Quality and Save Money – Microwave Digestion rules out Open Digestion

Improve Digestion Quality and Save Money – Microwave Digestion rules out Open Digestion

Reliable elemental analysis results need robust sample preparation to destroy sample matrices or to separate matrix from analytes. The sample preparation step is by far the most error-prone and critical step of the analytical procedure.

The influence of Surface Roughness on Instrumented Indentation Testing (IIT)

The influence of Surface Roughness on Instrumented Indentation Testing (IIT)

Microwave Assisted Digestion of Diatoms

Microwave Assisted Digestion of Diatoms

MD-VF-Auto SEM represents a powerful combination of microwave digestion, vacuum filtration and automated scanning electron microscopy for the qualitative and quantitative determination of diatoms.

In-Situ observation of the scratch/indentation true contact area to provide analysis without being model-dependent

In-Situ observation of the scratch/indentation true contact area to provide analysis without being model-dependent

Nanoindentation approach to mechanical testing of extremely soft materials

Nanoindentation approach to mechanical testing of extremely soft materials

Nanotribological properties of Diamond like carbon thin flexible films on ACM rubber

Nanotribological properties of Diamond like carbon thin flexible films on ACM rubber

Spherical Nanoindentation of Polyacrylamide Hydrogels using the Bioindenter (BHT)

Spherical Nanoindentation of Polyacrylamide Hydrogels using the Bioindenter (BHT)

The Ultra Nanoindentation Tester: New generation of thermal drift free indentation

The Ultra Nanoindentation Tester: New generation of thermal drift free indentation

Milk: Know the particles, know the quality

Milk: Know the particles, know the quality

The size of the fat particles in milk can vary, which strongly affects milk quality. Characterizing milk-based particles is fast and accurate with the Litesizer™ 500.

Applications of nanoindentation in biology and medicine

Applications of nanoindentation in biology and medicine

Nanoindentation for biological materials

Intrinsic bone tissue quality is altered in osteo-porosis and selectively influenced by its treatments

Intrinsic bone tissue quality is altered in osteo-porosis and selectively influenced by its treatments

Nanoindentation for bone and mineral materials

Identifying three different particle sizes in one sample with DLS

Identifying three different particle sizes in one sample with DLS

Particle suspensions often contain more than one size of particle. However, many particle analyzers cannot resolve particle mixtures, instead they detect an average of all sizes. The Litesizer™ 500 can detect three sizes in one sample.

An insight into the Structure of Copolymer Surfactants

An insight into the Structure of Copolymer Surfactants

The structure of inhomogeneous (core-shell) nanoparticles was studied with the SAXSpoint system. The internal structure of Pluronic P123 micelles in water was determined by calculating the radial electron density profile.

Collagen - A Validation Sample for SAXS Systems

Collagen - A Validation Sample for SAXS Systems

The performance of the SAXSpoint 2.0 system is evaluated by measurements of tendon collagen. SAXSpoint 2.0 produces data with excellent resolution in the entire angular range and delivers true 2D SWAXS images.

Understanding Filter Efficiency - Virus Removal in Depth Filtration

Understanding Filter Efficiency - Virus Removal in Depth Filtration

Zeta potential, as the indicator for surface charge, helps to predict and to tune the efficiency of filter materials.

Effect of Bleaching on the Streaming Potential of Human Hair

Effect of Bleaching on the Streaming Potential of Human Hair

The streaming potential method reveals the changes of the hair surface upon hair treatment processes and supports the optimization of cosmetic products.

Inner Surface Treatment of Haemodialysis Membranes

Inner Surface Treatment of Haemodialysis Membranes

The zeta potential measurement assists in the improvement of the biocompatibility of haemodialysis membranes.

SAXSpoint with MetalJet Source

SAXSpoint with MetalJet Source

SAXSpoint now integrates the high-brightness MetalJet X-ray source enabling ultra-fast SAXS measurements in the laboratory.

Fast SAXS studies of sensitive biological samples

Fast SAXS studies of sensitive biological samples

Small-angle X-ray scattering (SAXS) measurements of low-concentrated and radiation-sensitive biological samples using line collimation ensure short measurement time and allow to analyze the low-resolution 3D structure with excellent data quality.

Correlating Viscosity and Particle Size Parameters determined by Small Angle X-Ray Scattering Studies of concentrated MAb Solutions

Correlating Viscosity and Particle Size Parameters determined by Small Angle X-Ray Scattering Studies of concentrated MAb Solutions

Monoclonal antibodies (MAb) solutions are a major class of biopharmaceuticals with various applications. However, challenges like a high viscosity at the required MAb concentrations need to be addressed at an early development stage.

Targeting Alzheimer’s disease - studying the fibril structure of the Amyloid beta protein on a laboratory system

Targeting Alzheimer’s disease - studying the fibril structure of the Amyloid beta protein on a laboratory system

The fibril structure of Amyloid beta has been studied with the SAXSpoint 2.0 system.

Size and shape of gold nanoparticles in toluene via SAXS

Size and shape of gold nanoparticles in toluene via SAXS

A solution of colloidal gold nanoparticles was characterized for size and shape by the SAXSpace system.

Benefits

Differentiating between normal and pathological red blood cells

Anton Paar’s MCR rheometer is an excellent tool for monitoring the rheological characteristics of whole blood. At low shear stress, for example, red blood cells adhere to each other, aggregate, and form rouleaux. Using an MCR with a microscope accessory allows you to monitor changes in blood under various conditions through the microscope lens during the measurement. This combined information enables the correlation of the rheological properties of red blood cells to their aggregation state. Whole blood samples can be investigated according to the Recommendation of the International Committee for Standardization in Hematology.

Investigating the fouling of membranes and improving their biocompatibility

An economical and effective adsorbent for low-density lipoprotein (LDL) in blood is a dialysis membrane which is based on polysulfone with covalently bound heparin. However, problems inherent in the applicability of membranes in hemodialysis are surface-induced blood coagulation and membrane fouling due to irreversible protein adsorption. To improve the biocompatibility of these hemodialysis membranes, the inner surface of the membrane requires modification. A major challenge inherent to this process is the permanent coating with heparin. The grafting of reactive groups onto the polysulfone surface is one route to prepare the interface for the immobilization of such biologically active substances. The SurPASS electrokinetic analyzer is applied for analyzing the inner surface of such hollow-fiber membranes. Comparing the zeta potential of untreated and modified membranes reveals the efficiency of the surface treatment. The isoelectric point, which is obtained automatically, and the zeta potential values at higher pH are an indication that the grafting of reactive groups and the coating with heparin were successful.

Ensuring the safety of IV infusions

A common risk from intravenous infusions is contamination by particles that are not visible to the eye. To detect these unwanted particles and monitor the quality of IV infusions requires an analyzer such as Anton Paar’s Litesizer 500 which determines the particle size and particle size distribution of a solution quickly and from very small sample amounts (from 12 µL). The measurement meets the requirement of the US Pharmacopoeia for parenteral products which defines the size of droplets in emulsions and solutions to be infused or injected.

Assessing the level of trace elements in urine, blood, and hair

Evaluating trace element concentrations using, for example, ICP-MS/ICP-DRCMS and ETAAS requires sample solutions which are completely digested in order to minimize spectral and matrix interferences in the measurement. Microwave-assisted pressure digestion provides one such reliable method of sample preparation. Multiwave PRO, for example, decomposes body fluids and hair to produce high-quality samples in a short period of time. 

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