Biotechnological samples
In-depth study of sample properties to understand complex processes and interactions
Gaining information on the behavior of materials used in fields such as applied immunology, molecular engineering, and genetic engineering can be as simple as determining the concentration of substances at different temperatures – and as complex as characterizing nanostructures and their behavior under different conditions. Anton Paar is a pioneer in many of the required fields of measurement technology and analysis methods.
Anton Paar Products
Anton Paar Bioindenter:
UNHT³ Bio
Automated Multipurpose Powder X-Ray Diffractometer:
XRDynamic 500
Benchtop density meter:
DMA 4101
Benchtop density meter:
DMA 4501
Benchtop density meter:
DMA 5001
Compact digital density meter:
DMA 1001
Compact Raman spectrometers:
Cora 5001 Direct
Compact Raman spectrometers:
Cora 5001 Fiber
Density and sound velocity meter:
DSA 5000 M
Digital heavy duty refractometer:
Abbemat 450
Digital heavy duty refractometer:
Abbemat 650
Digital performance refractometer:
Abbemat Performance 300
Digital performance refractometer:
Abbemat Performance 500
Digital performance refractometer:
Abbemat Performance Plus 350
Digital performance refractometer:
Abbemat Performance Plus 550
Domed Cooling Stage for Four-Circle Goniometers:
DCS 500
Dynamic shear rheometer measuring head:
DSR 502
Electrokinetic analyzer for solid surface analysis:
SurPASS 3 Eco
Electrokinetic analyzer for solid surface analysis:
SurPASS 3 Standard
Fully customizable laboratory automation solution:
HTX
Handheld density meter:
DMA 35 Basic
Handheld Raman spectrometer:
Cora 100
Inline refractometer:
L-Rix 4100
Inline refractometer:
L-Rix 5100
Inline refractometer:
L-Rix 5200
Micro Combi Tester:
MCT³
Microwave digestion platform:
Multiwave 5000
Microwave digestion system:
Multiwave 7000
Microwave digestion system:
Multiwave GO Plus
Microwave reactor:
Monowave 200
Microwave reactor:
Monowave 400
Microwave reactor:
Monowave 450
Millikelvin thermometers:
MKT 10
Millikelvin thermometers:
MKT 50
Modular compact polarimeter:
MCP 100
Modular compact polarimeter:
MCP 150
Modular Compact Rheometer:
MCR 702e MultiDrive
Modular Compact Rheometer:
MCR 702e Space MultiDrive
Modular Compact Rheometer:
MCR 72/92 MCR 72
Modular Compact Rheometer:
MCR 72/92 MCR 92
Modular Compact Rheometer:
MCR 102e/302e/502e MCR 102e
Modular Compact Rheometer:
MCR 102e/302e/502e MCR 302e
Modular Compact Rheometer:
MCR 102e/302e/502e MCR 502e Power
Motorized alignment for XRD:
z-alignment stage
Nano scratch tester:
NST³
Nanoindentation tester:
NHT³
Particle size analyzer:
Litesizer 100
Particle size analyzer:
Litesizer 500
Pin-on-disk tribometer:
TRB³
Revetest® Scratch Tester:
RST³
Rheometer automation for high sample throughput and complex sample handling:
HTR
Rolling-ball viscometer:
Lovis 2000 M/ME
Rotational Rheometer:
RheolabQC
SAXS/WAXS/BioSAXS system:
SAXSpace
SAXS/WAXS/GISAXS/RheoSAXS laboratory beamline:
SAXSpoint 5.0
Ultra nanoindentation tester:
UNHT³ Standard
Vacuum Tribometer:
TRB V / THT V
Benefits
Studying the kinetics of transport processes shown by nanostructured emulsion droplets to ensure successful drug delivery control
When investigating the potential application of micelles as vehicles for the delivery of active ingredients, stability determinations have to be complemented by studying the micelles' internal structure. Since their internal structure depends on their composition, time-resolved SAXS experiments can be used to monitor the structure changes involved in the transport kinetics of nanostructured emulsion droplets, such as the uptake and release of active ingredients like vitamins and enzymes. The main requirements for successful time-resolved SAXS experiments, high intensity along with high resolution, are met by SAXSpace, which delivers high-quality data at short measurement times.
Researching the elastic and mechanical properties of hydrogels
Many hydrogels are considered to be potential candidates for replacement, regeneration, scaffolds, or as growth substrates for soft tissues in the human body. Recent research (Discher et al., 2005; Moers et al., 2013) has shown that the elasticity of the substrate can significantly influence the homeostasis of tissues, which is important for tissue regeneration. Determination of the elastic and mechanical properties of biological substrates is therefore of great interest. Elastic modulus and creep properties can easily be studied with Anton Paar’s Bioindenter as the instrument is compatible with testing in liquids and can operate under various loading modes. The time-dependent response of hydrogels can also be studied.
Determining the intrinsic viscosity and molar mass
The biological effects of hyaluronan can be tailored for pharmaceutical purposes by changing its molar mass. Hyaluronan has a short half-life in the body; for some purposes, e.g. in plastic surgery, its stability has to be increased by increasing the molecular mass. The Lovis 2000 M/ME microviscometer determines the viscosity of dissolved hyaluronan. The intrinsic viscosity is automatically calculated from the relative viscosity of hyaluronan and its solvent. The intrinsic viscosity provides the same information content as the molar mass. Nevertheless, the molar mass can also be calculated according to the Mark-Houwink equation and read directly off the screen. If required, the shear rate dependency can be eliminated by performing an automated zero shear rate extrapolation.
Investigating surface properties to ensure biocompatibility of implants
Surface properties such as the surface charge indicate a surface’s biocompatibility. Depending on the application of a biomaterial, a surface with high or low affinity to proteins is required. In tissue engineering and regenerative medicine, protein adsorption induces the integration of implants while in other cases high protein adhesion may lead to thrombus formation. Zeta potential analysis using Anton Paar’s SurPASS provides information on the surface charge at physiological pH and the chemistry of surface functional groups. The sign and magnitude of the zeta potential are used to estimate the electrostatic interaction between the solid surface and a charged species dissolved in the surrounding aqueous solution.
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