Biotechnological samples

In-depth study of sample properties to understand complex processes and interactions

Gaining information on the behavior of materials used in fields such as applied immunology, molecular engineering, and genetic engineering can be as simple as determining the concentration of substances at different temperatures – and as complex as characterizing nanostructures and their behavior under different conditions. Anton Paar is a pioneer in many of the required fields of measurement technology and analysis methods.

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Anton Paar Products

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Anton Paar Bioindenter: UNHT³ Bio

Automated Multiparameter Measurement: HTX

Automatisches Verdünnungs- und Dosiersystem DDS

Automatic Dilution and Dosage System: DDS

Automatisches Prozesspolarimeter Propol

Automatic Process Polarimeter: Propol

Ball Mill: BM500

Cora 7X00 Raman Spectrometer with Fiber-optic probe

Benchtop Raman spectrometers: Cora 7X00

Cora 5X00 Raman Spectrometer

Compact Raman spectrometers: Cora 5X00

Cryo & Humidity Chamber CHC plus+ is a unique combination of the multi-purpose CHC Cryo & Humidity Chamber and an advanced humidity (RH) generator for the analysis of humidity-dependent and/or temperature-dependent structural changes in materials using X-ray diffraction

Cryo & Humidity Chamber: CHC plus⁺

Density and sound velocity meter: DSA 5000 M

Density meter: DMA 1001

Density meter: DMA 4100 M

Density meter: DMA 4500 M

Density meter: DMA 5000 M

Abbemat Performance and Performance Plus

Digital Refractometer: Abbemat Performance

Domed Cooling Stage for Four-Circle Goniometers: DCS 500

Dynamic shear rheometer measuring head: DSR 502

Electrokinetic Analyzer for Routine Solid Surface Analysis: SurPASS™ 3 Eco

Electrokinetic Analyzer: SurPASS

Gas sorption analyzer: autosorb IQ

Handheld density meter: DMA 35 Basic

Handheld Raman spectrometer: Cora 100

Abbemat Heavy Duty

Heavy Duty Refractometer: Abbemat Heavy Duty

HTR Compact: Rheometer autosampler for high sample throughput

HTR: Rheometer automation for high sample throughput and complex sample handling

Inline Oxygen sensor: Oxy 510

Inline Refractometer: L-Rix

Low-Temperature Chamber: TTK 600

MCP 100 Modular Circular Polarimeter

MCP 150

MCP 150 Modular Compact Polarimeter

Micro Combi Tester: MCT³

Micro Scratch Tester: MST³

Microindentation Tester: MHT³

The acid digestion rotor 16HF100 with 16 high pressure vessels is designed for high sample throughput and efficient handling.

Microwave Digestion Rotor: 16HF100

Microwave digestion system: Multiwave GO Plus

Microwave reactor for microwave-assisted extractions: Monowave 450

Based on a revolutionary new technique, the all-new Masterwave BTR benchtop reactor for the first time transfers microwave synthesis to the kilolab. Productivity in your lab is considerably increased up to kilogram amounts per day. The benchtop reactor’s magnetically driven paddle stirrer provides independent stirring regimes for individual content. Due its rising-sensor temperature measurement technique, Masterwave BTR features the high temperature accuracy required for direct method transfer from any smaller microwave device.

Microwave Synthesis in the Kilolab: Masterwave BTR

Microwave Synthesis: Monowave 400/200

Millikelvin Thermometers: MKT

Modular Compact Rheometer: MCR 72/92

Modular Compact Rheometer: MCR 102/302/502

Motorized alignment for XRD: z-alignment stage

Nano scratch tester: NST³

Nanoindentation tester: NHT³

Particle Size Analyzer: Litesizer 100

Particle Size Analyzer: Litesizer 500

pH value measuring module: pH ME

Pin-on-disk tribometer: TRB³

Portable density meter: DMA 35

Revetest® Scratch Tester: RST³

Rolling-ball viscometer: Lovis 2000 M/ME

The RheolabQC is the quality control rheometer from Anton Paar. RheolabQC with temperature device C-PTD 180/AIR/QC and with Flexible Cup Holder.

Rotational Rheometer: RheolabQC

SAXS/WAXS/GISAXS/RheoSAXS laboratory beamline: SAXSpoint 5.0

Software for particle analysis: Kalliope™

SAXSpace instrument

SWAXS Diffractometer: SAXSpace

Top View mounted T-probe with Rotor 8N of Multiwave PRO.

T-probe

Ultra nanoindentation tester: UNHT³

High Temperature Vacuum Tribometer

Vacuum Tribometer: VTHT / VTRB

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Anton Paar Applications

Lactose Purity According to Pharmacopoeia

Lactose Purity According to Pharmacopoeia

The US and the European pharmacopoeias demand the analysis of the purity of lactose monohydrate polarimetrically. Determining the specific rotation with an MCP polarimeter from Anton Paar ensures high-quality products.

Glycerol

Glycerol

Glycerol is used in various industries as a moisturizer, a thickener, as antifreeze or as a precursor for explosives. Its quality as well as its concentration in solution can be determined by using refractometry.

Quality Control in Drugs

Quality Control in Drugs

Polarimeters are essential in drug quality control to ensure the enantiomeric purity and therefore efficacy of pharmaceutical drugs.

Quality Control of Saline Solution

Quality Control of Saline Solution

Abbemat refractometers from Anton Paar are valuable instruments for the precise analysis of concentration and purity of saline solutions.

Improve Digestion Quality and Save Money – Microwave Digestion rules out Open Digestion

Improve Digestion Quality and Save Money – Microwave Digestion rules out Open Digestion

Reliable elemental analysis results need robust sample preparation to destroy sample matrices or to separate matrix from analytes. The sample preparation step is by far the most error-prone and critical step of the analytical procedure.

In-Situ observation of the scratch/indentation true contact area to provide analysis without being model-dependent

In-Situ observation of the scratch/indentation true contact area to provide analysis without being model-dependent

Nanoindentation approach to mechanical testing of extremely soft materials

Nanoindentation approach to mechanical testing of extremely soft materials

Nanotribological properties of Diamond like carbon thin flexible films on ACM rubber

Nanotribological properties of Diamond like carbon thin flexible films on ACM rubber

Review of Indenter Materials for High Temperature Nanoindentation

Review of Indenter Materials for High Temperature Nanoindentation

Spherical Nanoindentation of Polyacrylamide Hydrogels using the Bioindenter (BHT)

Spherical Nanoindentation of Polyacrylamide Hydrogels using the Bioindenter (BHT)

The Ultra Nanoindentation Tester: New generation of thermal drift free indentation

The Ultra Nanoindentation Tester: New generation of thermal drift free indentation

Gold nanoparticles: Size matters, and so does stability

Gold nanoparticles: Size matters, and so does stability

Gold nanoparticles are now used in many fields, from medicine to electronics, but each application has specific particle-size and stability requirements. Gold nanoparticles can be easily monitored with the Litesizer™ 500.

Applications of nanoindentation in biology and medicine

Applications of nanoindentation in biology and medicine

Nanoindentation for biological materials

Intrinsic bone tissue quality is altered in osteo-porosis and selectively influenced by its treatments

Intrinsic bone tissue quality is altered in osteo-porosis and selectively influenced by its treatments

Nanoindentation for bone and mineral materials

Identifying three different particle sizes in one sample with DLS

Identifying three different particle sizes in one sample with DLS

Particle suspensions often contain more than one size of particle. However, many particle analyzers cannot resolve particle mixtures, instead they detect an average of all sizes. The Litesizer™ 500 can detect three sizes in one sample.

Nanoparticles for Ceramics: Size, Stability & pH

Nanoparticles for Ceramics: Size, Stability & pH

In nanoparticle suspensions that will be used in ceramics, particle size and stability are of vital importance. Suspension stability is essential to ensure that the particles to stay in suspension, and maintain constant particle size.

Temperature-dependent GISAXS studies on thin films

Temperature-dependent GISAXS studies on thin films

The temperature-induced decomposition of a thin film structure has been studied using the SAXSpoint system with the new temperature-controlled GISAXS stage.

An insight into the Structure of Copolymer Surfactants

An insight into the Structure of Copolymer Surfactants

The structure of inhomogeneous (core-shell) nanoparticles was studied with the SAXSpoint system. The internal structure of Pluronic P123 micelles in water was determined by calculating the radial electron density profile.

Collagen - A Validation Sample for SAXS Systems

Collagen - A Validation Sample for SAXS Systems

The performance of the SAXSpoint 2.0 system is evaluated by measurements of tendon collagen. SAXSpoint 2.0 produces data with excellent resolution in the entire angular range and delivers true 2D SWAXS images.

Understanding Filter Efficiency - Virus Removal in Depth Filtration

Understanding Filter Efficiency - Virus Removal in Depth Filtration

Zeta potential, as the indicator for surface charge, helps to predict and to tune the efficiency of filter materials.

Surface Modification of Kapton® Films

Surface Modification of Kapton® Films

The zeta potential is a valuable parameter to follow polymer surface modifications and to tailor-make biocompatible devices for medical applications.

Inner Surface Treatment of Haemodialysis Membranes

Inner Surface Treatment of Haemodialysis Membranes

The zeta potential measurement assists in the improvement of the biocompatibility of haemodialysis membranes.

Tuning of Solid Surface Properties by Self-Assembled Monolayers

Tuning of Solid Surface Properties by Self-Assembled Monolayers

The zeta potential measurement assists in tailoring the properties of technical and biomedical surfaces using self-assembled monolayers.

Correlating Viscosity and Particle Size Parameters determined by Small Angle X-Ray Scattering Studies of concentrated MAb Solutions

Correlating Viscosity and Particle Size Parameters determined by Small Angle X-Ray Scattering Studies of concentrated MAb Solutions

Monoclonal antibodies (MAb) solutions are a major class of biopharmaceuticals with various applications. However, challenges like a high viscosity at the required MAb concentrations need to be addressed at an early development stage.

Studying the Effect of Tear Fluid on Contact Lenses

Studying the Effect of Tear Fluid on Contact Lenses

The zeta potential indicates changes in the surface chemistry of contact lenses upon wearing and is thus suited to study biocompatible surface coatings.

Size and shape of gold nanoparticles in toluene via SAXS

Size and shape of gold nanoparticles in toluene via SAXS

A solution of colloidal gold nanoparticles was characterized for size and shape by the SAXSpace system.

Benefits

Studying the kinetics of transport processes shown by nanostructured emulsion droplets to ensure successful drug delivery control

When investigating the potential application of micelles as vehicles for the delivery of active ingredients, stability determinations have to be complemented by studying the micelles' internal structure. Since their internal structure depends on their composition, time-resolved SAXS experiments can be used to monitor the structure changes involved in the transport kinetics of nanostructured emulsion droplets, such as the uptake and release of active ingredients like vitamins and enzymes. The main requirements for successful time-resolved SAXS experiments, high intensity along with high resolution, are met by SAXSpace, which delivers high-quality data at short measurement times.

Researching the elastic and mechanical properties of hydrogels

Many hydrogels are considered to be potential candidates for replacement, regeneration, scaffolds, or as growth substrates for soft tissues in the human body. Recent research (Discher et al., 2005; Moers et al., 2013) has shown that the elasticity of the substrate can significantly influence the homeostasis of tissues, which is important for tissue regeneration. Determination of the elastic and mechanical properties of biological substrates is therefore of great interest. Elastic modulus and creep properties can easily be studied with Anton Paar’s Bioindenter as the instrument is compatible with testing in liquids and can operate under various loading modes. The time-dependent response of hydrogels can also be studied.

Determining the intrinsic viscosity and molar mass

The biological effects of hyaluronan can be tailored for pharmaceutical purposes by changing its molar mass. Hyaluronan has a short half-life in the body; for some purposes, e.g. in plastic surgery, its stability has to be increased by increasing the molecular mass. The Lovis 2000 M/ME microviscometer determines the viscosity of dissolved hyaluronan. The intrinsic viscosity is automatically calculated from the relative viscosity of hyaluronan and its solvent. The intrinsic viscosity provides the same information content as the molar mass. Nevertheless, the molar mass can also be calculated according to the Mark-Houwink equation and read directly off the screen. If required, the shear rate dependency can be eliminated by performing an automated zero shear rate extrapolation.

Investigating surface properties to ensure biocompatibility of implants

Surface properties such as the surface charge indicate a surface’s biocompatibility. Depending on the application of a biomaterial, a surface with high or low affinity to proteins is required. In tissue engineering and regenerative medicine, protein adsorption induces the integration of implants while in other cases high protein adhesion may lead to thrombus formation. Zeta potential analysis using Anton Paar’s SurPASS provides information on the surface charge at physiological pH and the chemistry of surface functional groups. The sign and magnitude of the zeta potential are used to estimate the electrostatic interaction between the solid surface and a charged species dissolved in the surrounding aqueous solution.