Biotechnological samples
In-depth study of sample properties to understand complex processes and interactions
Gaining information on the behavior of materials used in fields such as applied immunology, molecular engineering, and genetic engineering can be as simple as determining the concentration of substances at different temperatures – and as complex as characterizing nanostructures and their behavior under different conditions. Anton Paar is a pioneer in many of the required fields of measurement technology and analysis methods.
Anton Paar Products
MCR 703 MultiDrive
MCR 703 Space MultiDrive
XRDynamic 500
HTR 7000
Abbemat Essential 3001
Abbemat Essential 3101
Abbemat Essential 3201
UNHT³ Bio
DMA 1002
DMA 502
DMA 6002 Sound Velocity
Cora 5001 Direct Pharma
Cora 5001 Direct Standard
Cora 5001 Fiber Pharma
Cora 5001 Fiber Process Monitoring
Cora 5001 Fiber Standard
Litesizer DIA 100
Litesizer DIA 500
Litesizer DIA 700
Litesizer DLS 101
Litesizer DLS 501
Litesizer DLS 701
MCR 703 MultiDrive
DSR 502
SurPASS 3 Eco
SurPASS 3 Standard
MCR
Lyza 3000
Lyza 7000
Cora 100
Autosorb
Autosorb 6100
Autosorb 6200
Autosorb 6300
L-Dens 7400
L-Dens 7500
L-Rix
MCT³
Multiwave
Monowave
Monowave 200
Monowave 400
Monowave 450
MKT 10
MKT 50
DMA 4002
DMA 5002
DMA 6002
MCP 100
MCP 150
Polymer Measurement Systems
Polymer Measurement Systems Configuration 1
Polymer Measurement Systems Configuration 2
Wort Measurement System
NST³
NHT³
TRB³
DMA 35 Standard
RST
MCR Rheometer + Cora 5001
Lovis 2001 Benchtop
Lovis 2001 Module
RheolabQC
SAXSpoint 500
SAXSpoint 700
SAXSpace
UNHT³
TRB V / THT V
Studying the kinetics of transport processes shown by nanostructured emulsion droplets to ensure successful drug delivery control
When investigating the potential application of micelles as vehicles for the delivery of active ingredients, stability determinations have to be complemented by studying the micelles' internal structure. Since their internal structure depends on their composition, time-resolved SAXS experiments can be used to monitor the structure changes involved in the transport kinetics of nanostructured emulsion droplets, such as the uptake and release of active ingredients like vitamins and enzymes. The main requirements for successful time-resolved SAXS experiments, high intensity along with high resolution, are met by SAXSpace, which delivers high-quality data at short measurement times.
Researching the elastic and mechanical properties of hydrogels
Many hydrogels are considered to be potential candidates for replacement, regeneration, scaffolds, or as growth substrates for soft tissues in the human body. Recent research (Discher et al., 2005; Moers et al., 2013) has shown that the elasticity of the substrate can significantly influence the homeostasis of tissues, which is important for tissue regeneration. Determination of the elastic and mechanical properties of biological substrates is therefore of great interest. Elastic modulus and creep properties can easily be studied with Anton Paar’s Bioindenter as the instrument is compatible with testing in liquids and can operate under various loading modes. The time-dependent response of hydrogels can also be studied.
Determining the intrinsic viscosity and molar mass
The biological effects of hyaluronan can be tailored for pharmaceutical purposes by changing its molar mass. Hyaluronan has a short half-life in the body; for some purposes, e.g. in plastic surgery, its stability has to be increased by increasing the molecular mass. The Lovis 2000 M/ME microviscometer determines the viscosity of dissolved hyaluronan. The intrinsic viscosity is automatically calculated from the relative viscosity of hyaluronan and its solvent. The intrinsic viscosity provides the same information content as the molar mass. Nevertheless, the molar mass can also be calculated according to the Mark-Houwink equation and read directly off the screen. If required, the shear rate dependency can be eliminated by performing an automated zero shear rate extrapolation.
Investigating surface properties to ensure biocompatibility of implants
Surface properties such as the surface charge indicate a surface’s biocompatibility. Depending on the application of a biomaterial, a surface with high or low affinity to proteins is required. In tissue engineering and regenerative medicine, protein adsorption induces the integration of implants while in other cases high protein adhesion may lead to thrombus formation. Zeta potential analysis using Anton Paar’s SurPASS provides information on the surface charge at physiological pH and the chemistry of surface functional groups. The sign and magnitude of the zeta potential are used to estimate the electrostatic interaction between the solid surface and a charged species dissolved in the surrounding aqueous solution.
