L-Rix 510: Determination of Concentration on Producing Dialysis Products

L-Rix 510 – Enjoy the simplicity of refractive index measurements without maintenance or adjustments.

How to Produce Membranes and Filters for Dialysis

Dialysis patients often die from cardiovascular diseases. However, innovative membranes or filters filtrating the patient's blood can reduce the risk factors for these diseases. An important parameter for the effectiveness of membranes is their performance, which can be set by the composition of the precipitant. The precipitant - depending on the application – consists of different active substances, in this case a commonly used solvent DMAC (dimethylacetamide), in combination with water. The concentration ratio is an important quality parameter.

Where can the Refractometer be used for Concentration Measurement?

In particular the refractive index (RI) is suitable for measuring the concentration of DMAC in water as shown in the graph below. Regardless of the concentration, a density measurement provides only narrow differences. As the measured sound velocity has a reversal point, it is only suitable for limited concentration ranges.
The refractive index shows a significant, linear behavior over a wide measuring range and is therefore ideally suited for this concentration measurement. The maintenance-free and highly accurate Anton Paar inline refractometer L-Rix 510 provides the concentration and temperature of the product continuously - thus the process can be monitored around the clock.

        

 

 

Products

Specifications L-Rix 510
Refractive Index1.3100 to 1.5400
AccuracynD ±0.0002
(equivalent to 0.1% mass)
Repeatability nD ±0.0001 (equivalent to ±0.05% mass)
Process temperature -20 °C to 100 °C; CIP/SIP up to 145 °C for 30 minutes
Process pressure100 mbar to 16 bar
(10 bar @ 120 °C)
Approvals and certificationsEHEDG (European Hygienic Equipment Design Group) certified; Hygienic Design acc.to 3A standard 46-02

Other relevant instruments

Laboratory Instruments:

  • Abbemat Series