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Powder Rheology in Pharmaceutical Processing

Pharmaceutical powders are often assigned a single flow classification, but manufacturing exposes them to changing stress, humidity, temperature, fluidization, consolidation, and equipment surfaces. Those conditions can transform the powder or separate it into fractions with different behavior, which can adversely affect consistency in the final product. 

In this webinar, we will first establish how cohesion, shear flowability, compression, and wall friction answer different manufacturing questions. We will then examine how moisture and drying produce excipient-specific changes in flow and granule strength, followed by a root-cause investigation in which segregation creates a fine fraction with elevated wall friction and progressively deteriorating discharge. The conclusion is that successful powder characterization requires testing the process-relevant powder state under the process-relevant condition.

Key takeaways:

  • Understand how cohesion, shear flowability, compression, and wall friction provide different insights into pharmaceutical powder behavior
  • Learn how moisture, drying, and segregation can alter powder flow, granule strength, and manufacturing consistency
  • Discover how testing powders under process-relevant conditions can help identify root causes of flow and discharge problems and support more reliable pharmaceutical processing
Mr. John Raia (Idioma: English)
John Raia

John Raia graduated from the University of Minnesota Twin Cities in 2012 with a bachelor's degree in chemistry and has spent over a decade working with advanced scientific instrumentation. He specializes in rheology, with deep expertise in powder rheology and viscoelastic materials characterization, drawing on a broader analytical background in particle characterization to inform his approach to material behavior.

As a Principal Application Scientist at Anton Paar, he supports industries ranging everywhere from pharmaceuticals to cosmetics, food products and polymers, providing hands-on training and technical expertise that helps users understand how materials flow and interact. He leads the central region's Rheology Boot Camp, a four-day hands-on training course for MCR rheometer users, and is known for making complex concepts accessible, excelling at connecting classical rheology theory to practical, real world applications