e-SPRESSO WEBINAR: Solid dosage formulations: density, porosity and pore size from powder to tablet
The development and manufacture of pharmaceutical solid dosage formulations is an interesting particle engineering problem involving physicochemical surface properties and macroscopic behaviors. Often, control of the manufacturing process is affected by the lack of certain vital statistics about the raw materials – both active ingredients and excipients. The porosity and pore size distribution of the voids between powder particles is a function of particle shape, size, packing, and applied pressure.
• Powder flow and packing by tapped density
• Skeletal density measurements by gas pycnometry
• Porosity evaluation using gas pycnometry
• Interparticle pore size distributions by mercury intrusion porosimetry
In this webinar, you will learn how to measure pore properties through particle enlargement (granulation), low-pressure compression (e.g. ribbons), and high-pressure compaction (tableting).
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