Rheological Tests in the Pharmaceutical Industry Using the Example of Hyaluronic Acid

This application report explains various rheological standard tests for the characterization, improvement and quality control of samples in the pharmaceutical industry. Hyaluronic acid is used to show how rheological measurements can help in all four life stages of a pharmaceutical sample: formulation, processing, storage and application.

Working with pharmaceuticals can be very demanding. Rheological measurements are one of the best ways to help improve all four phases of the life cycle of a pharmaceutical product, namely formulation, processing, storage and application. During the formulation process, the influence of additives on bioadhesion or sensory perception can be observed. Optimization, monitoring and quality control during the processing steps are as important as knowledge of the thermal stability and shelf life of the product during storage. Good applicability, whether swallowing, spraying or spreading, can be a decisive factor for a customer to choose one pharmaceutical product over another.

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