Rheological Study of Highly Concentrated Protein Solution
Bovine Serum Albumin, Pharmaceuticals, Formulation, Rheometer, Subcutaneous Drug Delivery, Small Volume, Large Molecules
This application report examines the impact of adding 0.5 M sodium chloride to highly concentrated Bovine Serum Albumin (BSA) solutions (300 mg/mL), a common procedure for adjusting BSA properties such as ionic strength, aggregation behavior, structural stability and solubility, among others. Compared to the pristine BSA solution, the addition of sodium chloride results in a lower shear viscosity. As such large molecular weight solutions are expensive, there is a special focus on the use of small sample volumes for testing, such as in cone-plate measuring systems. In combination with the excellent low torque specifications of the MCR Rheometers, Anton Paar offers an excellent solution for measuring the viscosity of protein solutions
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