Parallel Synthesis at its Best
The use of silicon carbide materials has revolutionized microwave-assisted synthesis. Since silicon carbide (SiC) shows extremely fast heating rates under microwave irradiation, distributes heat very quickly and is chemically inert, different accessories for microwave reactors have been made out of SiC. Besides passive heating elements and reaction vessels, reaction blocks in plate format are well acknowledged in scientific and industrial research.
Nowadays, the term “time equals money” becomes more and more important for any industrial branch. Consequently, all processes have to be perfectly optimized, while the potential for further optimization is constantly evaluated.
In the field of chemical synthesis, an enormous increase of efficiency can be achieved by using dedicated microwave equipment. Reaction times can be significantly reduced while product purities and yields are improved.
This time-saving improvement can be achieved either by using sequential automation, or by performing several chemical reactions in parallel. In fact, sequential processing (even if automated) becomes impractical when a large number of optimization experiments need to be performed. Consequently, applications like library generation, reaction screening or biomedical and bioanalytical (forensic) investigations can be significantly enhanced by performing synthesis reactions in parallel.
This report highlights the use of silicon carbide plates, assisting the significant enhancement of different applications – ranging from reaction optimization over library generation (both often used in industrial drug discovery processes) to forensic investigations.
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