Nanoindentation methodology for assessment of rat femoral cartilage mechanical properties using the Bioindenter

Osteoarthritis is a disease that causes progressive damage to articular cartilage which leads to pain and reduced mobility. In its early stages the disease attacks the cartilage and changes its mechanical properties. This application report shows how nanoindentation can help in local characterization of mechanical properties of rat’s cartilage.

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the breakdown of joint cartilage, intra-articular inflammation of the synovium tissue and remodeling of trabecular and cortical subchondral bone. Despite the wide range of cartilage biomechanical testing methods in samples harvested from human or large animal models, rodent models – which have an increasingly prominent role in OA research – are still lacking suitable biomechanical assessment of their cartilage. Therefore, it is mandatory to develop an easy technique dedicated to the evaluation of the cartilage tissue quality in these
animal models.

The aim of this application report is to demonstrate specific indentation test procedure for measurement of mechanical properties of rat.

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