Medical | Lovis 2000 M/ME and DMA 4500 M: Viscosity Measurement of Whole Blood
Increased blood viscosity is correlated with all known risk factors for cardiovascular diseases including high blood pressure, cholesterol, diabetes, and side-effects of smoking. Lovis 2000 M/ME Microviscometer allows for comprehensive blood viscosity measurement. Low sample volume, a built-in software compliant to GMP and 21 CFR part 11, as well as optionally available pharma qualification packages round off the advantages.
The viscosity of blood is a direct measure of the ability of blood to flow through arteries and veins. It determines how much friction the blood causes against the vessels, how hard the heart has to work to pump the blood through the body, and how much oxygen is delivered to organs and tissue. Blood viscosity is correlated with all known risk factors for cardiovascular diseases. Elevated blood viscosity is a strong independent predictor of cardiovascular events. While serum or plasma viscosity measurements play an important role in the clinical management of patients prone to hyper-viscosity syndrome, these tests do not account for hematocrit, blood cell deformability or factors increasing RBC (red blood cell) aggregation. Whole blood is a non-Newtonian liquid. Its viscosity changes with the applied shear stress. The blood viscosity rises and falls from one extreme to the other with every cardiac cycle, comparable to blood pressure. Therefore, a meaningful blood viscosity test requires more than one measurement: systolic blood viscosity (high shear rate), which is affected by hematocrit, and plasma viscosity and diastolic viscosity (low shear rate), which is affected by several factors like stickiness of platelets, immune complexes that increase the aggregation of RBCs, triglycerides, cholesterol, and many more.
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