Lactose Monohydrate: Density and Surface Area - Nova and Ultrapyc

Lactose monohydrate, found in over-the-counter medications such as acetaminophen, loratadine, and cetirizine, is often used in formulations as a filler Its structural properties were determined on the Anton Paar Nova (with 21 CFR part 11 compliance) and the Ultrapyc.


Lactose monohydrate is used in the pharmaceutical industry primarily as a filler, adding bulk to products by binding and even stabilizing active ingredients. To prove its suitability for a formulation, researchers must determine various physical properties of the material - such as specific surface area (SSA) and skeletal density. Understanding these properties of the lactose monohydrate as a raw material is essential in guaranteeing consistency in the finished product.

A commercially-available lactose monohydrate was characterized using Anton Paar instruments, for:

  • SSA using a Nova 800 BET with Kaomi for Nova 21 CFR Part 11 software
  • Skeletal density using an Ultrapyc 5000

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