Granulation and Drying: the Choice of Excipients Matters

Solid dosage forms are not only made of active pharmaceutical ingredients (API) but also of excipients which improve the powder processing and the quality of the final dosage form. The success of multiple step process such as tableting and capsule filling depends on the parameters of instruments used and powder handling. Granulation and drying, in particular, require a suitable combination of excipients. This application report investigates the moisture uptake capacity of the excipients milled and sieved lactose as well as methylcellulose in order to estimate their behavior during wet granulation. The same excipients were also tested at different temperatures to reproduce the drying effect. It was found that the amount of moisture adsorbed during wet granulation and the consecutive temperature effect during drying have an impact on the flow and compression characteristics.

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