Fast Structure Analysis of Pharmaceutical Excipients by SWAXS for Product Quality Control

The nanostructure of pharmaceutical excipients used as taste masking agents was rapidly determined for quick quality control by small-angle X-ray scattering.


Small- and wide-angle X-ray scattering (SWAXS) is a powerful tool to characterize samples containing nano-sized lamellar structures. These structures play an important role in pharmaceutical applications for the development and characterization of new drug formulations.

SAXS determines the self-assembled (nano-sized) structures of such materials, i.e. lamella repeat dis-tance and long range order. WAXS determines the crystallinity at the atomic level and therefore delivers the characteristic fingerprint of these materials.

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