Applications of Bioindenter in biology and medicine

Indentation of biological materials became very popular in the last decade thanks to development of devices capable of measuring kPa modulus samples. The main areas explored include cartilage, cornea, and various types of hydrogels for tissue engineering. This document shows typical applications of local characterization of biological materials.

Anton Paar has for many years been active in the field of micromechanical testing of biological materials and biomaterials. After gaining significant experience in testing of hard biological materials such as dentin or bone in both dry and liquid environments, the next natural step was to evolve in the domain of soft tissues and materials. The ever increasing testing needs from the biology and medical community for characterization of soft biological and biocompatible materials initiated the development of a technique for localized testing of soft materials and a suitable testing device.
The nature of the samples whose stiffness is very low (elastic modulus of ~10 MPa and less) dictated the requirements of the new instrument and of the corresponding nanoindentation technique. The new nanoindentation tester for biologists should therefore fulfill these specifications:
▪ Low load range,
▪ Large vertical displacement range,
▪ Ability to test immersed samples,
▪ Automated procedure for testing irregularly shaped samples
In addition, the new nanoindentation device should to offer visualization features, good thermal stability, sufficient lateral repositioning accuracy for localized testing and heating option to reproduce biological environments.

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