Particle Size and Zeta Potential of CBD Beverage Emulsions
CBD legalization boosts edible product R&D. Because CBD is lipophilic, nanoemulsions enhance solubility and bioavailability. Particle size and zeta potential are key; the Litesizer DLS 500 delivers precise DLS/ELS analysis.
Introduction
The human endocannabinoid system regulates a wide array of essential functions via cannabinoid receptors, including physiological and cognitive processes such as appetite, pain sensation, mood and fertility[1],[2]. Cannabidiol (CBD) and tetrahydrocannabinol (THC), prevalent in hemp (industrial strains of Cannabis sativa) and marijuana plants, respectively, both mimic the chemical structure of the endocannabinoids naturally produced by the body.
The most important difference between THC and CBD is that THC has a psychoactive effect. This is due to the differences in how both substances interact with cannabinoid 1 receptors (CB1), which are mainly expressed in the central nervous system. THC has a high affinity for CB1 receptors, leading to a euphoric intoxication effect. CBD, although structurally very similar to THC, has a low affinity to CB1 receptors and acts in a more antagonistic way.
References
- Addiction, European Monitoring Centre for Drugs and Drug. Medical use of cannabis and cannabinoids. 2018.
- Köfalvi, Attila. Cannabinoids and the Brain. s.l. : Springer-Verlag US, 2008.
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