Pharmaceuticals | A case study of continuous density measurement: Determination of Critical Micelle Concentration Using Continuous Sound Velocity Measurement
Formulation development often requires the identification of concentration-dependent changes in liquid systems. In this application note, continuous sound velocity measurements were used to monitor such changes during the stepwise addition of concentrated sodium dodecyl sulfate stock solution to an aqueous SDS sample. The approach supports real-time detection of micelle formation and can assist in determining suitable surfactant and additive concentrations.
Process and formulation development often require time-resolved monitoring of quality-relevant parameters. Such measurements can help determine whether a solution remains stable, a reaction has reached completion, or a maximum concentration of a component can be used under defined conditions. Continuous measurements are therefore useful when changes in liquid properties must be followed during an ongoing process, concentration change, or formulation step.
Unlike standard single-point measurements, continuous data acquisition records the instrument signal over time. This allows trends, transitions, and characteristic changes in sample properties to be evaluated directly. In this application note, the approach is demonstrated using the determination of the critical micelle concentration (CMC) of sodium dodecyl sulfate (SDS). The determination of the critical micelle concentration (CMC) was selected as a case study, as micelle formation results in a clearly detectable change in sound velocity.
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