Analysis and Identification of Carbamazepine Polymorphs Using Differential Scanning Calorimetry (DSC)
Carbamazepine was selected as a model API to investigate pharmaceutical polymorphism. To detect thermal transitions between crystal forms and their identification, Differential Scanning Calorimetry (DSC) was used. The use of this technique allows the different polymorphic forms of carbamazepine to be distinguished and monitored. This study highlights DSC as complementary tool for polymorph control and characterization.
Crystalline compounds can exist in different crystal forms, known as polymorphs, which may exhibit different physicochemical properties. In the case of active pharmaceutical ingredients (APIs), identifying and controlling polymorphism is particularly important, since different crystal forms can display differences in solubility, dissolution behavior, stability, manufacturability, and ultimately bioavailability. In some cases, different forms may show similar performance but differ in stability or production cost, which further motivates polymorph screening during pharmaceutical development.
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