Pharma | Rotational Viscosity Testing of Ointments with ViscoQC
How can viscosity testing support quality control of pharmaceutical semi-solids? This application report shows how simple viscosity measurements of pharmaceutical formulations with ViscoQC 100/300 help to obtain steady, perfect consistency of medicinal suspensions.
Ointments, creams and lotions comprise the largest part of semi-solids in pharmaceutical industry. The consistencies of semi-solids during formulation must be monitored for quality control. In addition, regulations of pharmacopeias like USP and Ph. Eur. must be followed. The viscosity of ointments, for example, has an impact on several stages in the production: It must be possible to pump them, pack them, and squeeze them out of the packing easily and apply them to the target body areas. For the final reason, viscosities of ointments have to decrease when a force (“shear”) is applied (e.g. rubbing action). Therefore, perfect spreadability can only be obtained with a shear-thinning flow behavior of ointments. Rotational viscometers like ViscoQC 100 and ViscoQC 300 are the instruments of choice for quick quality control checks at the production line.
Experiment
| Instrument | ViscoQC 100 - R | ViscoQC 300 - H |
|---|---|---|
| Measurement type | Single-point | Multi-point |
| Spindle | T-B | CC18 |
| Accessories | Heli-Plus | PTD 80 |
| Speed in rpm | 8 | 20 to 100 |
| Temperature in °C | approx. 23 | 25 |
| Sample | A (paste-like) | B / C / D (liquid-like) |
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