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Material Brief: Microcrystalline Cellulose – BET Surface Area – Nova 600

Microcrystalline cellulose was analyzed using N2 (77 K) adsorption on the Nova 600 with 21 CFR part 11 compliance software. The BET surface area was calculated from the data. Compliance with US Pharmacopeia <846> Method II is demonstrated.

Microcrystalline cellulose (MCC) is a naturally occurring polymer found in plant cell walls that is insoluble in water and resistant to reaction. An important property of this material is the BET surface area. MCC surface area correlates to its ability to compact or compress in powders or tablets and generally how it interacts with the components of the food, pharma, or cosmetic mixture. For the pharmaceutical industry, procedures for measuring BET surface area are given in USP <846>. The Anton Paar Nova 600 complies with this international standard and was used to measure a commercially-available microcrystalline cellulose.

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