Accuracy, Repeatability and Reproducibility of the Litesizer DIA series

The Litesizer DIA series ensures accurate, repeatable, and reproducible particle size and shape analysis. Validated with ISO 13322 compliant reference standards with Dry Jet, Liquid Flow, and Free Fall dispersion units, it provides consistent results across instruments.

Dynamic image analysis is a direct measurement technique to determine the size and shape of particles moving in front of a camera. This application report exemplifies the excellent accuracy, repeatability and reproducibility of the Litesizer DIA series. The main focus will be on the Litesizer DIA 500 and 700 which both have more than one magnification available. However, Litesizer DIA 100 also has the 0.3x magnification which makes the data comparable. Furthermore, we will also examine the instrument repeatability and reproducibility.
The concepts of accuracy, repeatability, and reproducibility are central to evaluating the performance and reliability of the measurement system. The terms are narrowly defined by the ISO 13320 standard which actually defines laser diffraction. However, it is still relevant for dynamic image analysis as well. The following paragraph explains the relevant terminology in detail.
Accuracy refers to how close the measured particle size distribution is to the true or accepted reference value. While absolute accuracy can be challenging due to the complex nature of particle systems, ISO 13320 emphasizes the importance of method validation using appropriate reference materials or comparison with other established techniques.
Repeatability denotes the degree of agreement between consecutive measurements performed under identical conditions (same operator, instrument, sample, location). High repeatability is essential to ensure that the system delivers consistent results during routine use.
Reproducibility involves the consistency of results for the same sample across different laboratories, instruments, or operators. ISO 13320 highlights the need for inter-laboratory studies and proper method standardization to ensure comparability of data. Only the ISO from 2009 still contains a proper definition for the reproducibility

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