White paper: Quality Control of Cyclodextrin-API Inclusion Complexes with the Multiparameter Measurement System
Density, sound velocity, and refractive index measurements obtained with a multiparameter measurement system provide precise insights into Cyclodextrin-API complex formation. This approach supports efficient formulation optimization and ensures reliable quality control of the API, excipients, and final products.
Bioavailability is a crucial factor in drug development, as it determines how effectively an active pharmaceutical ingredient (API) reaches its site of action. However, many promising drug candidates suffer from poor water solubility, which can severely limit their absorption and therapeutic performance. Improving solubility is therefore a central challenge in pharmaceutical formulation.
Phase solubility studies play an essential role in addressing this challenge. They provide valuable insights into the solubility enhancement potential of various formulation strategies and help characterize the interactions between APIs and excipients, such as cyclodextrins (CDs). By analyzing these interactions, formulators can better understand the complexation behavior and select optimal excipients to enhance drug solubility and, ultimately, bioavailability.
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