Lysozyme: Particle-Size Measurements by Dynamic Light Scattering
Proteins are essential in biochemical reactions, structural support, and molecular transport. For therapeutic applications, monitoring protein size is crucial. This report highlights the use of dynamic light scattering (DLS) to characterize the size of lysozyme in solution at very low concentrations.
Proteins have dynamic and diverse roles in the body, catalyzing biochemical reactions, forming receptors and channels in membranes, providing intracellular and extracellular scaffolding support, and transporting molecules within a cell or from one organ to another [1]. They play a crucial role in the treatment of many serious diseases, for which they are usually administered by parenteral routes (e.g. intravenously). In such applications, it is of vital importance to monitor the proteins' size and stability in solution, in order to optimize formulations.
In the present application report, dynamic light scattering (DLS) is used to characterize the size of a common protein, lysozyme.
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