Density and sound velocity for ethanol quantification in plasma protein fractionation
Ethanol concentration is a critical parameter in the plasma fractionation process, as it controls the selective precipitation of proteins. This study investigates the use of density and sound velocity measurements to monitor and regulate ethanol concentration in plasma fractionation samples from real production batches.
This laboratory study demonstrates that plasma fractionation can be effectively monitored using density and sound velocity measurements, with respect to ethanol concentration. The samples exhibit quasi-binary behavior upon ethanol addition, enabling the creation of custom reference methods using density, sound velocity, or a combination of both.
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