Characterizing different Formulations of Intimate Soap
Liquid soap and shampoo stability are crucial due to their complex formulations. This report shows a direct link between particle size and viscosity, and demonstrates how the Litesizer DLS 500 and an MCR rheometer provide complementary stability insights.
Liquid formulations of soap and shampoo are often complex products customized for highly specific needs. Their formulation consists of a mixture of surfactants and co-surfactants, which provide the detergent function, and up to several dozen additives such as moisturizers, conditioners, perfumes, colorings, preservatives and even pharmaceutically active components. (1)
One of those active substances is benzydamine hydrochloride, an anti-inflammatory, analgesic and antibacterial active compound. It is applied locally for the treatment of pain and irritations of various mucous membranes. This lipophilic, pH-neutral compound has a membrane-stabilizing effect which was shown to inhibit the degranulation of neutrophilic white blood cells and to stabilize lysosomes. This blocks the local release of innate immunity mediators, hence modulating pain and inflammation (2).
Soaps containing active ingredients are classified as drugs, making the exact characterization of their properties all the more important. In the present application report, measurement techniques combining particle characterization and rheology were used to characterize three formulations of intimate soap containing benzydamine hydrochloride. Using Litesizer DLS 500 and an MCR Rheometer, a direct link between particle size and viscosity was demonstrated, and complementary information on the stability of the final product was brought to light.
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