Pharma | Viscosity of Macrogol
Dynamic and kinematic viscosity of Macrogol was determined in accordance with the European Pharmacopeia. Lovis coupled with a DMA was found to be an efficient and reliable setup for determining the viscosity of pharmaceutical-grade Macrogol.
Macrogol, also known as polyethylene glycol (PEG), is a linear polyether compound formed by polymerization of ethylene oxide. Depending on its average molecular mass the appearance changes. Their physicochemical properties, particularly solubility, lubricity, hygroscopicity, and compatibility with a wide range of active ingredients, make them indispensable excipients in the pharmaceutical industry.
Macrogol is used in ointment bases, plasticizers, solvents, tablet lubricants, and stabilizers. It serves as key component in suppositories, ophthalmic formulations and oral liquids.
Requirements according to Ph. Eur.
The European Pharmacopeia monograph 1444 specifies the identification and purity requirements for Macrogol and includes viscosity determination as an essential parameter to confirm the average molecular mass. The prescribed method relies on dynamic or kinematic viscosity measurements of the substance at 20 °C. The mentioned monograph links viscosity ranges to specific Macrogol grades. Therefore, accurate viscosity measurements ensure correct classification of the material and verify that polymer chain length remains within the intended specification. Consistency in viscosity also reflects stability in raw materials and production processes, supporting pharmaceutical suppliers in meeting regulatory expectations for excipient quality.
Viscometry using Lovis
The rolling-ball principle of Lovis 2001 enables precise, low-volume viscosity measurements with excellent temperature stability and high repeatability.
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