Solvothermal Synthesis of Functionalized SPIONs

AP 13 – 21 – 200 034

Chemicals [CAS]

Chemicals
 (Name)

MW [g/mol]

Density [g/mL]

Amount [mmol]

Mass / Volume

10025-77-1

Iron(III) chloride hexahydrate

270.30

 

1.85

0.5 g

111-30-8

Glutaraldehyde (50% in H2O)

100.12

1.106

19.3

1.94 g / 3.5 mL

127-09-3

Sodium acetate

82.03

 

21.9

1.8 g

107-21-1

Ethylene glycol

62.07

1.113

solvent

15 mL

Keywords

Superparamagnetic iron oxide nanoparticles, magnetite nanocrystals, functionalized nanocomposites

Instrument

Monowave 200

Description

In a G30 vial the iron precursor was dissolved together with the sodium acetate in ethylene glycol under stirring. Glutaraldehyde was added and the mixture was stirred another 5 min at room temperature before being subjected to microwave irradiation. The target temperature was achieved within a 2 min ramp.

Workup

After cooling the precipitate was separated with a magnet, thoroughly washed with water and EtOH and dried.

Comments

The microwave process leads to much smaller nanoparticle with narrow size distribution in much shorter time than conventional heating.

The nanoparticles were further surface modified by adsorption of different amounts of myoglobin protein.

 

 

References

M. V. Sullivan, et al., Nanotechnology 2021, 32, 095502

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