Solid dosage formulations: density, porosity and pore size from powder to tablet

Solid dosage formulations: density, porosity and pore size from powder to tablet


The development and manufacture of pharmaceutical solid dosage formulations is an interesting particle engineering problem involving physicochemical surface properties and macroscopic behaviors. Often, control of the manufacturing process is affected by the lack of certain vital statistics about the raw materials – both active ingredients and excipients. The porosity and pore size distribution of the voids between powder particles is a function of particle shape, size, packing, and applied pressure.

Key insights:
• Powder flow and packing by tapped density
• Skeletal density measurements by gas pycnometry
• Porosity evaluation using gas pycnometry
• Interparticle pore size distributions by mercury intrusion porosimetry

In this webinar, you will learn how to measure pore properties through particle enlargement (granulation), low-pressure compression (e.g. ribbons), and high-pressure compaction (tableting).

Language: English
Trainer: Dr. Martin Thomas
Martin Thomas

Dr. Thomas, Anton Paar QuantaTec’s Chief Scientist, has more than 37 years of experience in powder and porous materials characterization, 27 of those with Quantachrome Instruments before Anton Paar’s acquisition in 2018. Dr. Thomas graduated from the University of Birmingham (UK) with a Master’s degree in analytical chemistry followed by a PhD in physical-inorganic chemistry. He is named co-inventor on eight patents relating to porous solids and their characterization, and is co-author of “Characterization of Porous Solids and Powders: Surface Area, Pore Size and Density” (published by Springer).


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