Surface Morphology of Pharmaceutical Solid Dosage Forms by Utilizing Atomic Force Microscopy

Pharmaceutical solid dosage forms are usually coated to control drug release and protect active pharmaceutical ingredients (APIs) from degradation. Tosca 400 AFM enables unbeatably efficient quantitative surface roughness measurements.

Tablet coating: Why analyze the surface?

Pharmaceutical solid dosage forms are usually coated to control drug release, to protect active pharmaceutical ingredients (APIs) from degradation in the stomach or in humid atmospheres, to provide a barrier to taste and smell, and for controlling dissolution. Atomic force microscopy is used to acquire topography information, where it has the advantage over SEM in that it can provide quantitative surface roughness and surface area measurements. Data on compositional distribution and porosity may also be discerned.
The coating materials of tablets are also frequentlystudied as “free” thin films by utilizing AFM so that the effects of the tablet core can be eliminated.

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