Organic Synthesis | Efficient Grignard Reaction under Sealed Vessel Conditions

The Grignard reaction is a powerful, frequently used organometallic transformation to add important structural motifs to carbonyl compounds resulting in secondary or tertiary alcohols. Since usually the low boiling THF is used as a solvent, closed vessel conditions and elevated temperatures can significantly enhance the reaction. This is best done in a conventional synthesis reactor.

The formation of organometallic Grignard reagents from halides and elemental magnesium is a rather tricky and often slow starting process. Prevention of moisture and air is crucial. Therefore standard reaction conditions in open vessels require special precautions to activate the magnesium and to keep the moisture away from the reagents.

Sealed vessel conditions allow for simple creation of inert atmosphere and elevated reaction temperatures, thus successful initiation and short reaction times are granted.

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