Characterizing the curing reaction.pdf

Eye drops are used to treat eye diseases. Tribology can be a helpful tool for understanding and improving the performance of eye drops. Within this study, tribological model system testing was used to mimic the eyelid-cornea contact. Complementary rheological measurements allow for a more comprehensive understanding of the lubrication mechanisms of eye drops.

Introduction

Tears cover the cornea and conjunctiva in human eyes. They serve different functions such as lubrication, prevention of drying of the eye surfaces, smoothing the surface for refraction of light and also

providing antimicrobial properties. In most individuals, the normal tear volume ranges from 3.4 µL to 10.7 µL. The tear fluid film typically consists of three layers:

  • Outer layer (anterior) with lipid components
  • Aqueous intermediate layer
  • Bottom layer with mucin

Each of the layers serves a specific purpose. The outer lipid layer prevents evaporation. The aqueous intermediate layer consists of ions, soluble mucins, and proteins (including enzymes). These enzymes can be important for the antimicrobial function of the tear fluid. The mucin in the bottom layer enables an improved wetting of the tear film on the hydrophobic ocular surface. The performance of tears can be limited due to diseases such as dry eye syndrome or an insufficient quantity or incorrect composition of tears. In such cases, eye drops provide a potential solution.

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