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Characterization of Wrinkle Formation in a Polymeric Drug Coating by Atomic Force Microscope

Surface structure of polymeric drug delivery coating plays an important role on controlled drug release. Due to unique integrated measurement workflow of the Tosca atomic force microscope, the surface texture and grain size were characterized with unprecedented efficiency.


Drug release from polymeric composite thin films is promising for buccal/transdermal pharmaceutical applications due to the enhanced bioavailability. There is a growing demand for smart drug delivery systems and for corresponding appropriate characterization methods to study stability and release behavior. The surface morphology has a strong impact on dissolution and delivery properties as well as the long term stability of the drug delivery system. Here we have used Tosca 400 atomic force microscope (AFM) to characterize a drug delivery system. It consists of clotrimazole as active pharmaceutical ingredients (API) and poly (2-hydroxyethyl methacrylate) (pHEMA) as the top barrier layer. pHEMA is a hydrogel which builds a protective barrier in dry state and enables drug delivery (diffusion of API) in wet state. 

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