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The unique Rotor 4x48MC Well Plate utilizes sealable silicon carbide microtiter plates with a common 6x8 matrix. Silicon carbide ensures utmost temperature homogeneity and even allows efficient application of low-absorbing solvents. Moreover, the sophisticated sealing mechanism (patent pending) enables for the first time reactions to be performed in a common microtiter format at elevated conditions. Operation limits of 200 °C and 20 bar open up exceptional avenues for reaction screening and lead optimization. Capable for 4 well plates, thus 192 reactions in parallel, this new rotor represents an effective tool for microwave-mediated combinatorial chemistry.
Benefits:
- Sophisticated CombiChem approach
- Utmost temperature homogeneity
- Effective application of low absorbing solvents
The high-throughput Rotor 64MG5 is specially designed for library generation of valuable targets and parallel method optimization. Its reliable setup features 64 disposable glass vials arranged in 16 groups of four. Effective sealing with modified screw caps allows using the 5 mL standard vials for reaction conditions of 200 °C and 20 bar as well.
Benefits:
- Inexpensive solution for high sample throughput
- Parallelism for efficient workflow
- Rapid cooling
The Rotor 48MF50 is designed for library generation in gram scale. Each reaction vessel consists of a 50 mL PFA liner, a pressure jacket made of reinforced PEEK and a screw cap containing a cone seal and a metal rupture disk for overpressure release (MF50). At an operation range of 200 °C and 20 bar, even small amounts such as only 6 mL in a single vessel can be processed effectively.
Reaction control is achieved on the center circle by IR control and more precisely by an immersing temperature/pressure sensor in one reference vessel.
Benefits
- Efficient vessel design - only three parts to handle
- Robust cone seals - no time consuming pre-forming necessary
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